Successful treatment of cerebral aspergillosis with a high oral dose of itraconazole after excisional surgery

被引：25
|
作者：
Imai, T [1 ]
Yamamoto, T [1 ]
Tanaka, S [1 ]
Kashiwagi, M [1 ]
Chiba, S [1 ]
Matsumoto, H [1 ]
Uede, T [1 ]
机构：
[1] Sapporo Med Univ, Sch Med, Dept Neurol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan
来源：
INTERNAL MEDICINE | 1999年 / 38卷 / 10期
关键词：
fungus infection; sphenoid sinus; brain abscess; MRI;
D O I：
10.2169/internalmedicine.38.829
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity, The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).
引用
收藏
页码：829 / 832
页数：4
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