5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp.

被引：0
|
作者：
Su, Tzu-Rong [1 ]
Liang, Kai-Ju [2 ,3 ]
Chiang, Michael Y. [4 ]
Lu, Mei-Chin [2 ,3 ]
Wu, Yu-Jen [5 ]
Su, Jui-Hsin [2 ,3 ]
机构：
[1] Antai Med Care Cooperat Antai Tian Sheng Mem Hosp, Pingtung 928, Taiwan
[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[3] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan
[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
[5] Meiho Univ, Dept Beauty Sci, Pingtung 912, Taiwan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 11期
关键词：
5; alpha; 8; alpha-Epidioxysterol; Sponge; Axinyssa; Cytotoxicity; TUMOR-CELL-LINES; MARINE SPONGES; LEAD COMPOUNDS; GENUS; ASSAY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new 5 alpha,8 alpha-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines.
引用
收藏
页码：1535 / 1536
页数：2
相关论文
共 50 条
  • [21] Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.
    Yen, Wei-Hsuan
    Hu, Li-Chung
    Su, Jui-Hsin
    Lu, Mei-Chin
    Twan, Wen-Hung
    Yang, Show-Ying
    Kuo, Yung-Chi
    Weng, Ching-Feng
    Lee, Chia-Hung
    Kuo, Yueh-Hsiung
    Sung, Ping-Jyun
    [J]. MOLECULES, 2012, 17 (12) : 14058 - 14066
  • [22] Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge Scalarispongia sp.
    Lee, Yeon-Ju
    Lee, Dong-Geun
    Rho, Hyun Soo
    Krasokhin, Vladimir B.
    Shin, Hee Jae
    Lee, Jong Seok
    Lee, Hyi-Seung
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (06) : 1400 - 1404
  • [23] NUCLEOSIDES FROM THE MARINE SPONGE Callyspongia SP.
    Huang, Riming
    Zhou, Xuefeng
    Peng, Yan
    Yang, Xianwen
    Xu, Tunhai
    Liu, Yonghong
    [J]. CHEMISTRY OF NATURAL COMPOUNDS, 2011, 46 (06) : 1010 - 1011
  • [24] Scalarane Sesterterpenes from the Sponge Smenospongia sp.
    Song, Jueun
    Jeong, Wooyeol
    Wang, Nan
    Lee, Hyi-Seung
    Sim, Chung J.
    Oh, Ki-Bong
    Shin, Jongheon
    [J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (11): : 1866 - 1871
  • [25] New sesterterpenes from the sponge Smenospongia sp.
    Rho, JR
    Lee, HS
    Shin, HJ
    Ahn, JW
    Kim, JY
    Sim, CJ
    Shin, J
    [J]. JOURNAL OF NATURAL PRODUCTS, 2004, 67 (10): : 1748 - 1751
  • [26] Norisoprenoids from the marine sponge Spheciospongia sp.
    Liu, Dong
    Xu, Min-Juang
    Wu, Li-Jun
    Deng, Zhi-Wei
    Lin, Wen-Han
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, 11 (09) : 811 - 816
  • [27] New polyketides from the Sponge plakortis sp.
    Braekman, JC
    Daloze, D
    De Groote, S
    Fernandes, JB
    Van Soest, RWM
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (08): : 1038 - 1042
  • [28] Steroids from an Australian Sponge Psammoclema sp.
    Holland, Ian P.
    McCluskey, Adam
    Sakoff, Jennette A.
    Gilbert, Jayne
    Chau, Ngoc
    Robinson, Phillip J.
    Motti, Cherie A.
    Wright, Anthony D.
    van Altena, Ian A.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (01): : 102 - 106
  • [29] Diketopiperazines from marine sponge Haliclona sp.
    Wang, Bin
    Huang, Riming
    Liu, Yonghong
    [J]. PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2, 2009, : 245 - 249
  • [30] Sterols from the Madagascar Sponge Fascaplysinopsis sp.
    Aknin, Maurice
    Gros, Emmanuelle
    Vacelet, Jean
    Kashman, Yoel
    Gauvin-Bialecki, Anne
    [J]. MARINE DRUGS, 2010, 8 (12): : 2961 - 2975
12345