5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp.

被引：0
|
作者：
Su, Tzu-Rong [1 ]
Liang, Kai-Ju [2 ,3 ]
Chiang, Michael Y. [4 ]
Lu, Mei-Chin [2 ,3 ]
Wu, Yu-Jen [5 ]
Su, Jui-Hsin [2 ,3 ]
机构：
[1] Antai Med Care Cooperat Antai Tian Sheng Mem Hosp, Pingtung 928, Taiwan
[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[3] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan
[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
[5] Meiho Univ, Dept Beauty Sci, Pingtung 912, Taiwan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 11期
关键词：
5; alpha; 8; alpha-Epidioxysterol; Sponge; Axinyssa; Cytotoxicity; TUMOR-CELL-LINES; MARINE SPONGES; LEAD COMPOUNDS; GENUS; ASSAY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new 5 alpha,8 alpha-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines.
引用
收藏
页码：1535 / 1536
页数：2
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