IgE-mediated anaphylactic reaction to purified and recombinant factor VIII in a patient with severe haemophilia A

被引：16
|
作者：
Kadar, J. G.
Schuster, J.
Hunzelmann, N.
机构：
[1] Klin & Poliklin Dermatol & Vererol, D-50931 Cologne, Germany
[2] Univ Cologne, Outpatient Clin, Cologne, Germany
[3] Univ Cologne, Lab Transfus Med, Cologne, Germany
[4] Univ Cologne, Dept Dermatol, Cologne, Germany
来源：
HAEMOPHILIA | 2007年 / 13卷 / 01期
关键词：
allergy; bleeding disorder; IgE-mediated reaction; inhibitors; recombinant;
D O I：
10.1111/j.1365-2516.2006.01339.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a 51-year-old patient with severe haemophilia A developing a severe life-threatening anaphylactic reaction to recombinant factor VIII (rFVIII). Anaphylactic reactions are a rare but well-known side effect of FVIII products. The nature of these reactions could not be clarified as previous studies failed to demonstrate a specific IgE response. Here, we could prove a grade 3 anaphlyactic reaction as an IgE-mediated response to rFVIII for the first time by Western blotting.
引用
收藏
页码：104 / 105
页数：2
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