IgE-mediated anaphylactic reaction to purified and recombinant factor VIII in a patient with severe haemophilia A

被引：16

作者：

Kadar, J. G.

Schuster, J.

Hunzelmann, N.

机构：

[1] Klin & Poliklin Dermatol & Vererol, D-50931 Cologne, Germany

[2] Univ Cologne, Outpatient Clin, Cologne, Germany

[3] Univ Cologne, Lab Transfus Med, Cologne, Germany

[4] Univ Cologne, Dept Dermatol, Cologne, Germany

来源：

HAEMOPHILIA | 2007年 / 13卷 / 01期

关键词：

allergy; bleeding disorder; IgE-mediated reaction; inhibitors; recombinant;

D O I：

10.1111/j.1365-2516.2006.01339.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 51-year-old patient with severe haemophilia A developing a severe life-threatening anaphylactic reaction to recombinant factor VIII (rFVIII). Anaphylactic reactions are a rare but well-known side effect of FVIII products. The nature of these reactions could not be clarified as previous studies failed to demonstrate a specific IgE response. Here, we could prove a grade 3 anaphlyactic reaction as an IgE-mediated response to rFVIII for the first time by Western blotting.

引用

页码：104 / 105

页数：2

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