Palladium-Catalyzed Allylic C-H Fluorination

被引：161
|
作者：
Braun, Marie-Gabrielle [1 ]
Doyle, Abigail G. [1 ]
机构：
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 35期
基金：
美国国家科学基金会;
关键词：
SYNTHETIC METHODS; ENANTIOSELECTIVE FLUORINATION; ASYMMETRIC-SYNTHESIS; FLUORIDE; ALKYLATION; AMINATION; EPOXIDES; OXIDATION; ALKENES; OLEFINS;
D O I：
10.1021/ja407223g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first catalytic allyllic C-H fluorination reaction using a nucleophilic fluoride source is reported. Under the influence of a Pd/Cr cocatalyst system, simple olefin substrates undergo fluorination with Et3N center dot 3HF in good yields with high branched:linear regioselectivity. The mild conditions and broad scope make this reaction a powerful alternative to established methods for the preparation of allylic fluorides from prefunctionalized substrates.
引用
收藏
页码：12990 / 12993
页数：4
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