Palladium-Catalyzed Intramolecular C-H Amination in Water

被引：30
|
作者：
Yang, Lizheng [1 ]
Li, Hao [1 ]
Zhang, Haifei [1 ]
Lu, Hongjian [1 ]
机构：
[1] Nanjing Univ, Inst Chem & BioMed Sci, Sch Chem & Chem Engn, Nanjing, Jiangsu, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 34期
基金：
中国国家自然科学基金;
关键词：
Amination; Azides; Nitrenes; Nitrogen heterocycles; Palladium; N BOND-FORMATION; ORGANIC-SYNTHESIS; RH-2(II)-CATALYZED SYNTHESIS; AZIDE COMPOUNDS; FUNCTIONALIZATION; ACTIVATION; CHEMISTRY; NITRENE; ARENES; EFFICIENT;
D O I：
10.1002/ejoc.201601043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium(II) catalysis was found to be effective for intramolecular C-H amination in water. With 2-azidobiphenyls as substrates, the reaction efficiently provided various carbazoles with N-2 as the sole byproduct. The reaction showed high functional-group tolerance and could be used in the synthesis of several natural carbazole alkaloids. The catalytic process was promoted by water, and the reaction was inefficient in the organic solvents that were investigated.
引用
收藏
页码：5611 / 5615
页数：5
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