Gastrointestinal tract effects of Securidaca longepedunculata root extract

被引：6
|
作者：
Olajide, OA [1 ]
Ajayi, FF
Ekhelar, AI
Awe, SO
Makinde, JM
Alada, ARA
机构：
[1] Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria
[2] Univ Ibadan, Coll Med, Dept Physiol, Ibadan, Nigeria
来源：
PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 02期
关键词：
Securidaca longepedunculata Fres; Polygalaceae; gastric emptying; gastric erosion; guinea-pig ileum; intestinal motility; laxative;
D O I：
10.1076/phbi.37.2.134.6078
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A methanol extract of the root of Securidaca longepedunculata has shown spasmodic actions on rite gastrointestinal tract of laboratory animals. An increase in the propulsive movements of the intestinal contents, its well as a reduction in gastric emptying time, was produced by the extract. The number of wet faeces was increased in mis after oral administration Preliminary studies on isolated guinea-pig ileum showed that the extract evoked contractions which were blocked by atropine. At a high dose. the extract produced ulcerations on gastric mucosa and small intestine.
引用
收藏
页码：134 / 137
页数：4
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