Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles

被引：100
|
作者：
Ding, Zhenhua [1 ]
Yoshikai, Naohiko [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 33期
基金：
新加坡国家研究基金会;
关键词：
alkenes; CH activation; cobalt; indoles; intramolecular reactions; C-H BOND; CROSS-COUPLING REACTIONS; CARBON-HYDROGEN BOND; AROMATIC IMINES; ORTHO-ALKYLATION; ACTIVATION; CYCLIZATION; ANNULATION; POTENT; HETEROCYCLES;
D O I：
10.1002/anie.201305151
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8574 / 8578
页数：5
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