Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles

被引：101

作者：

Ding, Zhenhua ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 33期

基金：

新加坡国家研究基金会;

关键词：

alkenes; CH activation; cobalt; indoles; intramolecular reactions; C-H BOND; CROSS-COUPLING REACTIONS; CARBON-HYDROGEN BOND; AROMATIC IMINES; ORTHO-ALKYLATION; ACTIVATION; CYCLIZATION; ANNULATION; POTENT; HETEROCYCLES;

D O I：

10.1002/anie.201305151

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regiodivergent catalysis: Cobalt N-heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N-homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8574 / 8578

页数：5

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