Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

被引：15
|
作者：
He, Zan [1 ]
Xin, Zijuan [2 ,3 ,4 ,5 ]
Yang, Qiong [2 ,3 ,4 ,5 ]
Wang, Chen [2 ,3 ,4 ,5 ]
Li, Meng [2 ,3 ,4 ,5 ]
Rao, Wei [1 ]
Du, Zhimin [1 ]
Bai, Jia [1 ]
Guo, Zixuan [6 ]
Ruan, Xiuyan [2 ,3 ,4 ,5 ]
Zhang, Zhaojun [2 ,3 ,4 ,5 ]
Fang, Xiangdong [2 ,3 ,4 ,5 ]
Zhao, Hua [1 ]
机构：
[1] Peoples Liberat Army, Dept Dermatol, Med Gen Hosp 1, Beijing, Peoples R China
[2] Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China
[3] Chinese Acad Sci, China Natl Ctr Bioinformat, Beijing, Peoples R China
[4] Univ Chinese Acad Sci, Beijing, Peoples R China
[5] Beijing Key Lab Genome & Precis Med Technol, Beijing, Peoples R China
[6] Peoples Liberat Army, Sr Dept Orthoped, Gen Hosp, Med Ctr 4, Beijing, Peoples R China
来源：
ELIFE | 2022年 / 11卷
基金：
中国国家自然科学基金;
关键词：
acral melanoma; single-cell RNA sequencing; tumor microenvironment; Human; Skin; IMMUNE CELLS; CANCER; FIBROBLASTS; METASTASIS; HALLMARKS; CARCINOMA; EXCLUSION; BLOCKADE; SURVIVAL; BIOLOGY;
D O I：
10.7554/eLife.78616
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumor microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as TWIST1, EREG, TNFRSF9, and CTGF could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF-CD44 and TNFSF9-TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents.
引用
收藏
页数：24
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