Transition-Metal-Free Synthesis of Quinoxalines from o-Phenylenediamines and Arylacetaldehydes under Basic Conditions

被引：13
|
作者：
Song, Jinli [1 ,2 ]
Li, Xiaolong [1 ,2 ]
Chen, Yongxin [1 ,2 ]
Zhao, Mingming [1 ,2 ]
Dou, Yani [1 ,2 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
来源：
SYNLETT | 2012年 / 16期
基金：
美国国家科学基金会;
关键词：
quinoxalines; o-phenylenediamine; arylacetaldehyde; oxidation; condensation; transition-metal-free; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; TANDEM PROCESS; DERIVATIVES; ECHINOMYCIN; ALKYNES; WATER;
D O I：
10.1055/s-0031-1290450
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for the synthesis of quinoxalines via transition-metal-free cyclization of o-phenylenediamine and arylacetaldehyde in a one-pot procedure has been developed. In this process, an inorganic base (K2CO3) is the only reagent required, and it proceeds smoothly in the absence of adding transition metal catalysts. The reaction appears to be very general and suitable for the construction of a variety of quinoxalines.
引用
收藏
页码：2416 / 2420
页数：5
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