A Transition-Metal-Free Synthesis of Multisubstituted Imidazoles

被引：10
|
作者：
Wu, Ping [1 ]
Zhang, Lutao [1 ]
Zhang, Xueguo [1 ]
Guo, Xin [1 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2016年 / 34卷 / 04期
基金：
中国国家自然科学基金;
关键词：
multisubstituted imidazoles; cyclization; benzamidine; N-tosyl-hydrazone; heterocycles; ONE-POT SYNTHESIS; CATALYZED DIRECT CYANATION; N-TOSYLHYDRAZONES; TERMINAL ALKYNES; ANTITUMOR EVALUATION; AMIDINES SYNTHESIS; BOND FORMATION; C-N; DERIVATIVES; ALKENES;
D O I：
10.1002/cjoc.201500759
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and simple t-BuOLi/I-2-mediated synthesis of 1,2,4-trisubstituted imidazoles was developed without transition-metal added. The transition-metal-free strategy tolerated a range of substrates and provided products in moderate to good yields with 100% regioselectivity.
引用
收藏
页码：363 / 367
页数：5
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