Nucleic acid amplification methodologies for the detection of pulmonary mold infections

被引：10

作者：

McCarthy, Matthew William ^{[1
]}

Petraitiene, Ruta ^{[2
]}

Walsh, Thomas J. ^{[3
]}

机构：

[1] Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Med, Hosp Med, New York, NY 10021 USA

[2] Cornell Univ, Dept Med, New York, NY 10021 USA

[3] Weill Cornell Med Ctr Transplantat, Dept Med, Oncol Infect Dis Program, New York, NY USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2017年 / 17卷 / 03期

关键词：

Aspergillosis; polymerase chain reaction; mucormycosis; fusarium; scedosporium; galactomannan; REAL-TIME PCR; INVASIVE FUNGAL-INFECTIONS; POLYMERASE-CHAIN-REACTION; ASPERGILLUS GALACTOMANNAN ANTIGENEMIA; BRONCHOALVEOLAR LAVAGE SAMPLES; CENTRAL-NERVOUS-SYSTEM; BETA-D-GLUCAN; IMMUNOCOMPROMISED PATIENTS; RAPID DETECTION; UNITED-STATES;

D O I：

10.1080/14737159.2017.1293528

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: The detection of pulmonary mold infections has historically required technically demanding methods obtained through invasive procedures. Nucleic acid amplification assays have the potential to circumvent the technical hurdles associated with diagnosis, but are not without potential pitfalls.Areas covered: In this paper, the authors review new assays for the diagnosis of pulmonary mold infections due to aspergillosis, mucormycosis, and hyalohyphomycoses as well as uncommon infections caused by dematiaceous molds.Expert commentary: Nucleic acid amplification assays have the potential to rapidly identify patients with invasive mycoses and could shorten the time to implementation of appropriate antimicrobial therapy. However, selection of appropriate patient populations will be crucial to ensure the highest Bayesian positive predictive value for any novel diagnostic platform.

引用

页码：271 / 279

页数：9

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