Strategies for signal amplification in nucleic acid detection

被引：80

作者：

Andras, SC

Power, JB

Cocking, EC

Davey, MR

机构：

[1] Univ Nottingham, Sch Biosci, Plant Sci Div, Nottingham NG7 2RD, England

[2] Univ Babes Bolyai, Fac Biol & Geol, Dept Ecol & Genet, R-3400 Cluj Napoca, Romania

来源：

MOLECULAR BIOTECHNOLOGY | 2001年 / 19卷 / 01期

关键词：

signal amplification; nucleic acid detection; in situ hybridization; in situ PCR; primed in situ labeling; self-sustained sequence replication; strand displacement amplification; ligase chain reaction; padlock probes; rolling circle amplification; tyramide signal amplification; branched DNA amplification;

D O I：

10.1385/MB:19:1:029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many aspects of molecular genetics necessitate the detection of nucleic acid sequences. Current approaches involving target amplification (in situ PCR, Primed in situ Labeling, Self-Sustained Sequence Replication, Strand Displacement Amplification), probe amplification (Ligase Chain Reaction, Padlock Probes, Rolling Circle Amplification) and signal amplification (Tyramide Signal Amplification, Branched DNA Amplification) are summarized in the present review, together with their advantages and limitations.

引用

页码：29 / 44

页数：16

共 50 条

[1] Strategies for signal amplification in nucleic acid detection
S. Calin Andras
J. Brian Power
Edward C. Cocking
Michael R. Davey
[J]. Molecular Biotechnology, 2001, 19 : 29 - 44
[2] Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection
Zhu, Yuanyuan
Wu, Jian
Zhou, Qingli
[J]. BIOSENSORS & BIOELECTRONICS, 2023, 230
[3] Signal enhancing strategies in aptasensors for the detection of small molecular contaminants by nanomaterials and nucleic acid amplification
Zhang, Nan
Li, Jingrong
Liu, Boshi
Zhang, Di
Zhang, Chengyu
Guo, Yuheng
Chu, Xinhong
Wang, Wenting
Wang, Haixia
Yan, Xiaohui
Li, Zheng
[J]. TALANTA, 2022, 236
[4] State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors
Gul, Ijaz
Raheem, Muhammad Akmal
Reyad-ul-Ferdous, Md.
Yuan, Xi
Chen, Zhenglin
lv, Chenying
Chen, Minjiang
Ji, Jiansong
Wu, Duanpo
Zhao, Qiang
Yan, Chenggang
Yu, Dongmei
[J]. Sensors and Actuators Reports, 2025, 9
[5] Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection
Chen, Yanglingzhi
Murayama, Keiji
Asanuma, Hiroyuki
[J]. CHEMISTRY LETTERS, 2022, 51 (03) : 330 - 333
[6] Advances in improvement strategies of digital nucleic acid amplification for pathogen detection
Xiang, Xinran
Shang, Yuting
Zhang, Jumei
Ding, Yu
Wu, Qingping
[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2022, 149
[7] SENSITIVE DETECTION OF NUCLEIC ACID BY SIGNAL AMPLIFICATION APPROACH BASED ON POLYMERIZATION COUPLED WITH ATP AMPLIFICATION
Zou Bingjie
Chen Ying
Huang Huan
Zhou Guohua
[J]. IFPT'6: PROGRESS ON POST-GENOME TECHNOLOGIES, PROCEEDINGS, 2009, : 431 - 433
[8] Nucleic acid amplification with specific signal filtration and magnification for ultrasensitive colorimetric detection
He, Hongfei
Zhou, Yan
Chen, Bin
Zhang, Yi
Zhong, Xiaowu
Xu, Lei
Guo, Bin
Yin, Chong
Zhou, Xi
Li, Qingrong
Huang, Zhen
Luo, Guangcheng
Guo, Xiaolan
[J]. TALANTA, 2023, 253
[9] Combining nucleic acid amplification and detection
Schweitzer, B
Kingsmore, S
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (01) : 21 - 27
[10] Nucleic acid amplification strategies for DNA microarray-based pathogen detection
Vora, GJ
Meador, CE
Stenger, DA
Andreadis, JD
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (05) : 3047 - 3054

← 1 2 3 4 5 →