Synthesis of 5,6-dihydropyridin-2(1H)-ones,1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-hexahydroquinolin-2(1H)-ones by intramolecular Wittig reaction

被引：18
|
作者：
Fisyuk, AS [1 ]
Poendaev, NV [1 ]
机构：
[1] Omsk State Univ, Dept Organ Chem, Omsk 644077, Russia
来源：
MOLECULES | 2002年 / 7卷 / 02期
关键词：
5,6-dihydropyridin-2(1H)-one; Wittig reaction; intramolecular cyclization; N-(3-oxoalkyl)chloroacetamide;
D O I：
10.3390/70200124
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new, universal and diastereospecific method has been developed for the synthesis of 5,6-dihydropyridin-2(1H)-ones, 1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-hexahydroquinolin-2(1H)-ones (4) based on the intramolecular Wittig cyclization of the triphenyphosphonium salts 2 derived from the N-(3-oxoalkyl)-chloroacetamides 1.
引用
收藏
页码：124 / 128
页数：5
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