Synthesis of 5,6-dihydropyridin-2(1H)-ones,1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-hexahydroquinolin-2(1H)-ones by intramolecular Wittig reaction

被引：18

作者：

Fisyuk, AS ^{[1
]}

Poendaev, NV ^{[1
]}

机构：

[1] Omsk State Univ, Dept Organ Chem, Omsk 644077, Russia

来源：

MOLECULES | 2002年 / 7卷 / 02期

关键词：

5,6-dihydropyridin-2(1H)-one; Wittig reaction; intramolecular cyclization; N-(3-oxoalkyl)chloroacetamide;

D O I：

10.3390/70200124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new, universal and diastereospecific method has been developed for the synthesis of 5,6-dihydropyridin-2(1H)-ones, 1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-hexahydroquinolin-2(1H)-ones (4) based on the intramolecular Wittig cyclization of the triphenyphosphonium salts 2 derived from the N-(3-oxoalkyl)-chloroacetamides 1.

引用

页码：124 / 128

页数：5

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