Phenomenological-Based model of the human pancreas and its role in glucose homeostasis

被引：0

作者：

Tutalcha Pame, Harrison Alberto ^{[1
]}

Davila Cabrera, Mario Alejandro ^{[1
]}

Lema Perez, Laura ^{[1
]}

机构：

[1] Univ Nacl Colombia, Proc & Energy Sch, Medellin, Colombia

来源：

2019 IEEE 4TH COLOMBIAN CONFERENCE ON AUTOMATIC CONTROL (CCAC): AUTOMATIC CONTROL AS KEY SUPPORT OF INDUSTRIAL PRODUCTIVITY | 2019年

关键词：

Semi-physical models; mathematical model; islets of Langerhans; process dynamics; pancreas; ISLET;

D O I：

10.1109/ccac.2019.8921124

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This work presents a Phenomenological-Based Semi-physical Model (PBSM) for the role of the pancreas in the glucose homeostasis. The model focuses on flow and concentration changes of insulin and glucagon that leaving the pancreas towards the portal vein, according to the levels of glucose detected by the pancreas in the bloodstream. Unlike other mathematical models, the PBSM obtained has a greater structural and parametric interpretability. The results obtained show a good agreement with respect to one sets of experimental data, in which adjustment factors are included to compensate the absence of paracrine effects in the model.

引用

页数：6

共 50 条

[31] The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy
Tan, Lay Shuen
Lau, Hwee Hui
Abdelalim, Essam M.
Khoo, Chin Meng
O'Brien, Richard M.
Tai, E. Shyong
Teo, Adrian Kee Keong
TRENDS IN MOLECULAR MEDICINE, 2025, 31 (02) : 152 - 164
[32] Phenomenological-based semi-physical model characterizing the central metabolic response of Escherichia coli to changes in batch culture temperature
Benavides-Lopez, Santiago
Ortega-Quintanab, Fabian A.
Alvarez, Hernan
BIOCHEMICAL ENGINEERING JOURNAL, 2024, 203
[33] Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism
Koenig, Matthias
Bulik, Sascha
Holzhuetter, Hermann-Georg
PLOS COMPUTATIONAL BIOLOGY, 2012, 8 (06)
[34] Role of probiotics in modulating glucose homeostasis: evidence from animal and human studies
Firouzi, Somayyeh
Barakatun-Nisak, Mohd Y.
Ismail, Amin
Majid, Hazreen Abdul
Azmi, Kamaruddin Nor
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2013, 64 (06) : 780 - 786
[35] EVIDENCE FOR A PHYSIOLOGIC ROLE OF PANCREATIC GLUCAGON IN HUMAN GLUCOSE HOMEOSTASIS - STUDIES WITH SOMATOSTATIN
GERICH, JE
LORENZI, M
HANE, S
GUSTAFSON, G
GUILLEMIN, R
FORSHAM, PH
METABOLISM-CLINICAL AND EXPERIMENTAL, 1975, 24 (02): : 175 - 182
[36] THE ROLE OF RETINOIC ACID IN MATURING THE INSULINOGENIC RESPONSE OF THE HUMAN FETAL PANCREAS TO GLUCOSE
TUCH, BE
DARBY, KB
OSGERBY, KJ
TRANSPLANTATION PROCEEDINGS, 1990, 22 (02) : 760 - 760
[37] SOMATOSTATIN MODULATION OF GLUCAGON-SECRETION AND ITS IMPORTANCE IN HUMAN GLUCOSE HOMEOSTASIS
GERICH, JE
METABOLISM-CLINICAL AND EXPERIMENTAL, 1978, 27 (09): : 1283 - 1290
[38] Modelling the Flow Behaviour of Al Alloy Sheets at Elevated Temperatures Using a Modified Zerilli-Armstrong Model and Phenomenological-Based Constitutive Models
Abd El-Aty, Ali
Xu, Yong
Hou, Yong
Zhang, Shi-Hong
Ha, Sangyul
Xia, Liangliang
Alzahrani, Bandar
Ali, Alamry
Ahmed, Mohamed M. Z.
Shokry, Abdallah
MATERIALS, 2024, 17 (07)
[39] The roles of ATF3 in glucose homeostasis - A transgenic mouse model with liver dysfunction and defects in endocrine pancreas
Allen-Jennings, AE
Hartman, MG
Kociba, GJ
Hai, T
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) : 29507 - 29514
[40] Human gut homeostasis and regeneration: the role of the gut microbiota and its metabolites
Marcela Arenas-Gomez, Claudia
Garcia-Gutierrez, Enriqueta
Escobar, Juan S.
Cotter, Paul D.
CRITICAL REVIEWS IN MICROBIOLOGY, 2023, 49 (06) : 764 - 785

← 1 2 3 4 5 →