Phenomenological-Based model of the human pancreas and its role in glucose homeostasis

被引：0
|
作者：
Tutalcha Pame, Harrison Alberto [1 ]
Davila Cabrera, Mario Alejandro [1 ]
Lema Perez, Laura [1 ]
机构：
[1] Univ Nacl Colombia, Proc & Energy Sch, Medellin, Colombia
来源：
2019 IEEE 4TH COLOMBIAN CONFERENCE ON AUTOMATIC CONTROL (CCAC): AUTOMATIC CONTROL AS KEY SUPPORT OF INDUSTRIAL PRODUCTIVITY | 2019年
关键词：
Semi-physical models; mathematical model; islets of Langerhans; process dynamics; pancreas; ISLET;
D O I：
10.1109/ccac.2019.8921124
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
This work presents a Phenomenological-Based Semi-physical Model (PBSM) for the role of the pancreas in the glucose homeostasis. The model focuses on flow and concentration changes of insulin and glucagon that leaving the pancreas towards the portal vein, according to the levels of glucose detected by the pancreas in the bloodstream. Unlike other mathematical models, the PBSM obtained has a greater structural and parametric interpretability. The results obtained show a good agreement with respect to one sets of experimental data, in which adjustment factors are included to compensate the absence of paracrine effects in the model.
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页数：6
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