Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation

被引：12
|
作者：
Sunderic, Milos [1 ]
Miljus, Goran [1 ]
Nedic, Olgica [1 ]
机构：
[1] Univ Belgrade, Inst Applicat Nucl Energy INEP, Belgrade 11080, Serbia
来源：
PROTEIN JOURNAL | 2013年 / 32卷 / 02期
关键词：
IGFBP-2; alpha; 2-macroglobulin; Protein complexes; proteolysis; PLASMA; ALPHA(2)-MACROGLOBULIN; COMPONENT;
D O I：
10.1007/s10930-013-9471-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with alpha 2-macroglobulin (alpha 2M), a protease inhibitor. Formation of IGFBP-2/alpha 2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.
引用
收藏
页码：138 / 142
页数：5
相关论文
共 50 条
  • [1] Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation
    Miloš Šunderić
    Goran Miljuš
    Olgica Nedić
    The Protein Journal, 2013, 32 : 138 - 142
  • [2] α2-macroglobulin:: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis
    Westwood, M
    Aplin, JD
    Collinge, IA
    Gill, A
    White, A
    Gibson, JM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) : 41668 - 41674
  • [3] Insulin-like growth factor-binding protein 1 and insulin-like growth factor-binding protein 3 in pre-eclampsia
    Wang, HS
    Lee, JD
    Cheng, BJ
    Soong, YK
    BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1996, 103 (07): : 654 - 659
  • [4] Insulin-like growth factor-binding protein 2 in tumorigenesis: Protector or promoter?
    Hoeflich, A
    Reisinger, R
    Lahm, H
    Kiess, W
    Blum, WF
    Kolb, HJ
    Weber, MM
    Wolf, E
    CANCER RESEARCH, 2001, 61 (24) : 8601 - 8610
  • [5] The insulin-like growth factor-binding protein superfamily
    Rosenfeld, RG
    Hwa, V
    Wilson, E
    Plymate, SR
    Oh, Y
    GROWTH HORMONE & IGF RESEARCH, 2000, 10 : S16 - S17
  • [6] Expression of insulin-like growth factor-binding protein 2 in melanocytic lesions
    Wang, HM
    Shen, SS
    Wang, H
    Diwan, AH
    Zhang, W
    Fuller, GN
    Prieto, VG
    JOURNAL OF CUTANEOUS PATHOLOGY, 2003, 30 (10) : 599 - 605
  • [7] Interaction of AIM with insulin-like growth factor-binding protein-4
    You, Qiang
    Wu, Yan
    Yao, Nannan
    Shen, Guannan
    Zhang, Ying
    Xu, Liangguo
    Li, Guiying
    Ju, Cynthia
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 36 (03) : 833 - 838
  • [8] COLOCALIZATION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN WITH INSULIN-LIKE GROWTH FACTOR-I
    KOBAYASHI, S
    CLEMMONS, DR
    VENKATACHALAM, MA
    AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (01): : F22 - F28
  • [9] Autoregulation of insulin-like growth factor 2 and insulin-like growth factor-binding protein 6 in periodontal ligament cells in vitro
    Konermann, A.
    Lossdoerfer, S.
    Jaeger, A.
    Chen, Y.
    Goetz, W.
    ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 2013, 195 (06) : 527 - 532
  • [10] Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation
    DeMambro, Victoria E.
    Maile, Laura
    Wai, Christine
    Kawai, Masanobu
    Cascella, Teresa
    Rosen, Clifford J.
    Clemmons, David
    JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (02) : 390 - 400
12345