Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation

被引：0
|
作者：
Miloš Šunderić
Goran Miljuš
Olgica Nedić
机构：
[1] University of Belgrade,Institute for the Application of Nuclear Energy (INEP)
来源：
The Protein Journal | 2013年 / 32卷
关键词：
IGFBP-2; α2-macroglobulin; Protein complexes; IGFBP-2 proteolysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with α2-macroglobulin (α2M), a protease inhibitor. Formation of IGFBP-2/α2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.
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页码：138 / 142
页数：4
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