Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation

被引：12
|
作者：
Sunderic, Milos [1 ]
Miljus, Goran [1 ]
Nedic, Olgica [1 ]
机构：
[1] Univ Belgrade, Inst Applicat Nucl Energy INEP, Belgrade 11080, Serbia
来源：
PROTEIN JOURNAL | 2013年 / 32卷 / 02期
关键词：
IGFBP-2; alpha; 2-macroglobulin; Protein complexes; proteolysis; PLASMA; ALPHA(2)-MACROGLOBULIN; COMPONENT;
D O I：
10.1007/s10930-013-9471-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with alpha 2-macroglobulin (alpha 2M), a protease inhibitor. Formation of IGFBP-2/alpha 2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.
引用
收藏
页码：138 / 142
页数：5
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