Synthesis and activities of bactobolin derivatives having new functionality at C-3

被引：9

作者：

Adachi, H ^{[1
]}

Nishimura, Y ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 01期

关键词：

D O I：

10.7164/antibiotics.55.92

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Some derivatives of bactobolin were prepared from bactobolin (1) by trans formation of the dichloromethyl group at C-3 to the hydroxymethyl, carboxylic acid, methanesulfonyloxymethyl and aldehydeoxime groups. The derivatives proved to be less active than the parent antibiotic 1 against bacteria as well as cytotoxicity, indicating that the functionality at C-3 considerably influences the biological activity.

引用

页码：92 / 98

页数：7

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