Synthesis and activities of bactobolin derivatives having new functionality at C-3

被引：9
|
作者：
Adachi, H [1 ]
Nishimura, Y [1 ]
Takeuchi, T [1 ]
机构：
[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 01期
关键词：
D O I：
10.7164/antibiotics.55.92
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Some derivatives of bactobolin were prepared from bactobolin (1) by trans formation of the dichloromethyl group at C-3 to the hydroxymethyl, carboxylic acid, methanesulfonyloxymethyl and aldehydeoxime groups. The derivatives proved to be less active than the parent antibiotic 1 against bacteria as well as cytotoxicity, indicating that the functionality at C-3 considerably influences the biological activity.
引用
收藏
页码：92 / 98
页数：7
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