Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile

被引：0

作者：

Hou, Shanshan ^{[1
]}

Zhou, Yuanzhang ^{[1
]}

Lu, Wei ^{[1
]}

Han, Jiaqian ^{[1
]}

Zhang, Ziwei ^{[1
]}

Xu, Shan ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering (MMME 2016) | 2016年 / 79卷

关键词：

2-(4-nitrobenzylidene) malononitrile; 3-(4-nitrophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; 3-(4-aminophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis; DERIVATIVES; INHIBITORS; DOCKING;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to synthesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially available 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and (HNMR)-H-1. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malononitrile).

引用

页码：476 / 478

页数：3

共 50 条

[41] Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)-1-(4-aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one
de Souza Nunes, Paula Hemilia
de Freitas, Thiago Sampaio
Rocha, Janaina Esmeraldo
Silva Pereira, Raimundo Luiz
Marinho, Marcia Machado
de Oliveira, Mateus Rodrigues
Oliveira, Larissa Santos
Marinho, Emanuelle Machado
Marinho, Emmanuel Silva
Aquino, Silvia Sousa
Sampaio Nogueira, Carlos Emidio
Melo Coutinho, Henrique Douglas
Bandeira, Paulo Nogueira
Rodrigues Teixeira, Alexandre Magno
dos Santos, Helcio Silva
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2022, 36 (06) : 1066 - 1082
[42] Reaction of 1-(2-Oxocyclohexyl)ethane-1,1,2,2-tetracarbonitrile with α,β-Unsaturated Aldehydes
Sheverdov, V. P.
Davydova, V. V.
Nasakin, O. E.
Maryasov, M. A.
Dorovatovskii, P. B.
Khrustalev, V. N.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (03) : 385 - 390
[43] N′-[1-(4-Aminophenyl)ethyl]pyrazine-2-carbohydrazide
Xing, Zhi-Yong
Yu, De-Cheng
Li, Lai-Jun
Liu, Hai-Yan
Zhang, Jian-Fei
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O544 - U4373
[44] SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF 3-(AMINOPHENYL)-2-SUBSTITUTEDISOINDOLIN-1-ONES
OKAZAKI, K
KUMAZAWA, T
MOCHIDA, K
OBASE, H
NITO, M
KUBO, K
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 57 - MEDI
[45] A 1:1 molecular complex of bis(4-aminophenyl) disulfide and 4-aminothiophenol
Vangala, VR
Desiraju, GR
Jetti, RKR
Bläser, D
Boese, R
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2002, 58 : O635 - O636
[46] Diastereoselective synthesis of functionalized spiro[cyclopropane-1,3′-indolines] and spiro[indoline-3,1′-cyclopropane-2′,3"-indolines]
Qi, Wen-Jie
Han, Ying
Yan, Chao-Guo
TETRAHEDRON, 2016, 72 (33) : 5057 - 5063
[47] Synthesis of 2-[2-(Ethoxymethoxy)phenyl]spiro[cyclopropane-1,2′-indene]-1′,3′-dione
Ivanova, Olga A. A.
Shorokhov, Vitaly V. V.
Andreev, Ivan A. A.
Ratmanova, Nina K. K.
Rybakov, Victor B. B.
Strel'tsova, Elena D. D.
Trushkov, Igor V. V.
MOLBANK, 2023, 2023 (01)
[48] 1-(4-Aminophenyl)ethanone isonicotinoyl-hydrazone
Chen, SS
Zhang, SP
Huang, CB
Shao, SC
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O31 - O32
[49] Synthesis of 2′-oxo-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2,2,3,3-tetracarbonitriles
Kayukova, O. V.
Kayukov, Ya. S.
Lapteva, E. S.
Bardasov, I. N.
Ershov, O. V.
Nasakin, O. E.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (09) : 1414 - 1416
[50] (E)-N′-[1-(4-aminophenyl)ethylidene]benzohydrazide
Shan, Shang
Tian, Yu-Liang
Wang, Shan-Heng
Wang, Wen-Long
Xu, Ying-Li
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1363 - U2799

← 1 2 3 4 5 →