Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile

被引：0

作者：

Hou, Shanshan ^{[1
]}

Zhou, Yuanzhang ^{[1
]}

Lu, Wei ^{[1
]}

Han, Jiaqian ^{[1
]}

Zhang, Ziwei ^{[1
]}

Xu, Shan ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering (MMME 2016) | 2016年 / 79卷

关键词：

2-(4-nitrobenzylidene) malononitrile; 3-(4-nitrophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; 3-(4-aminophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis; DERIVATIVES; INHIBITORS; DOCKING;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to synthesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially available 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and (HNMR)-H-1. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malononitrile).

引用

页码：476 / 478

页数：3

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