Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile

被引：0
|
作者：
Hou, Shanshan [1 ]
Zhou, Yuanzhang [1 ]
Lu, Wei [1 ]
Han, Jiaqian [1 ]
Zhang, Ziwei [1 ]
Xu, Shan [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China
来源：
Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering (MMME 2016) | 2016年 / 79卷
关键词：
2-(4-nitrobenzylidene) malononitrile; 3-(4-nitrophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; 3-(4-aminophenyl) cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis; DERIVATIVES; INHIBITORS; DOCKING;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to synthesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially available 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and (HNMR)-H-1. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malononitrile).
引用
收藏
页码：476 / 478
页数：3
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