LIPOPHILICITY ASSESSMENT OF SOME 5,5-DISUBSTITUTED HYDANTOINS BY THE MEANS OF REVERSED PHASE LIQUID CHROMATOGRAPHY

被引：0
|
作者：
Despotovic, Vesna [1 ]
Trisovic, Nemanja [2 ]
Mandic, Anamarija [3 ]
Uscumlic, Gordana [2 ]
Djakovic-Sekulic, Tatjana [1 ]
机构：
[1] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Novi Sad 21000, Serbia
[2] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
[3] Univ Novi Sad, Inst Food Technol, Novi Sad 21000, Serbia
来源：
CHEMICAL INDUSTRY & CHEMICAL ENGINEERING QUARTERLY | 2013年 / 19卷 / 01期
关键词：
R-m; R-w; log K-w; PC1; log P; lipophilicity; QUANTITATIVE STRUCTURE-RETENTION; PRINCIPAL COMPONENT ANALYSIS; MEDICINAL CHEMISTRY; DERIVATIVES; DESCRIPTORS; SYSTEMS; ACID; PCA; TLC;
D O I：
10.2298/CIEQ120124037D
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high petformance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC). The mobile phases were mixtures of methanol-water and acetonitrile-water in various volume fractions. In order to explore and visualize similarities and differences among the investigated compounds and chromatographic system, Principal Component Analysis (PCA) was used. Results show that the experimental lipophllicity indices estimated from retention data (R-m,R-w, log k(w)) and PC1 are directly correlated with logP values at a high significant statistical level.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 50 条
  • [41] REVERSED-PHASE LIQUID-CHROMATOGRAPHY OF SOME ALKALOIDS
    POPL, M
    KY, LD
    STRNADOVA, J
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1985, 23 (03) : 95 - 100
  • [42] The retention of some azoles in reversed-phase liquid chromatography
    S. V. Kurbatova
    O. V. Kharitonova
    E. E. Finkel’shtein
    Russian Journal of Physical Chemistry A, Focus on Chemistry, 2008, 82 : 1932 - 1937
  • [43] LIPOPHILICITY DETERMINATION OF NONHOMOLOGOUS SERIES OF NONIONIC SURFACTANTS BY MEANS OF REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY
    CSERHATI, T
    JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1993, 27 (02): : 133 - 142
  • [44] The retention behavior of some uracil derivatives in normal and reversed-phase chromatography. Lipophilicity of the compounds
    Perisic-Janjic, NU
    Uscumlic, GS
    Valentic, NV
    JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2005, 18 (102) : 92 - 97
  • [45] The lipophilicity indices of flavonoids estimated by reversed-phase liquid chromatography using different computation methods
    Briciu, Rodica Domnica
    Kot-Wasik, Agata
    Namiesnik, Jacek
    Sarbu, Costel
    JOURNAL OF SEPARATION SCIENCE, 2009, 32 (12) : 2066 - 2074
  • [46] STUDY OF THE LIPOPHILICITY OF ORGANIC-BASES BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY WITH ALKALINE ELUENTS
    DEBIASI, V
    LOUGH, WJ
    EVANS, MB
    JOURNAL OF CHROMATOGRAPHY, 1986, 353 : 279 - 284
  • [47] Study of pH and temperature effect on lipophilicity of catechol-containing antioxidants by reversed phase liquid chromatography
    Numviyimana, Claver
    Chmiel, Tomacz
    Kot-Wasik, Agata
    Namiesnik, Jacek
    MICROCHEMICAL JOURNAL, 2019, 145 : 380 - 387
  • [48] The Retention Behavior of Some Uracil Derivatives in Normal and Reversed-Phase Chromatography. Lipophilicity of the Compounds
    Nada U. Perišić-Janjić
    Gordana S. Usčumlić
    Nataša V. Valentić
    JPC – Journal of Planar Chromatography – Modern TLC, 2005, 18 : 92 - 97
  • [49] Determination of the Lipophilicity of Some New Thiosemicarbaside Derivatives by Reversed-Phase Thin-Layer Chromatography
    Hawryl, A.
    Kusmierz, E.
    Pisarczyk, P.
    Wujec, M.
    Waksmundzka-Hajnos, M.
    ACTA CHROMATOGRAPHICA, 2012, 24 (02) : 271 - 290
  • [50] LIPOPHILICITY DETERMINATION OF SOME NEW CROWN ETHERS BY REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY
    CSERHATI, T
    SZOGYI, M
    GYORFI, L
    CHROMATOGRAPHIA, 1985, 20 (04) : 253 - 260
12345