LIPOPHILICITY ASSESSMENT OF SOME 5,5-DISUBSTITUTED HYDANTOINS BY THE MEANS OF REVERSED PHASE LIQUID CHROMATOGRAPHY

被引：0

作者：

Despotovic, Vesna ^{[1
]}

Trisovic, Nemanja ^{[2
]}

Mandic, Anamarija ^{[3
]}

Uscumlic, Gordana ^{[2
]}

Djakovic-Sekulic, Tatjana ^{[1
]}

机构：

[1] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Novi Sad 21000, Serbia

[2] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia

[3] Univ Novi Sad, Inst Food Technol, Novi Sad 21000, Serbia

来源：

CHEMICAL INDUSTRY & CHEMICAL ENGINEERING QUARTERLY | 2013年 / 19卷 / 01期

关键词：

R-m; R-w; log K-w; PC1; log P; lipophilicity; QUANTITATIVE STRUCTURE-RETENTION; PRINCIPAL COMPONENT ANALYSIS; MEDICINAL CHEMISTRY; DERIVATIVES; DESCRIPTORS; SYSTEMS; ACID; PCA; TLC;

D O I：

10.2298/CIEQ120124037D

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high petformance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC). The mobile phases were mixtures of methanol-water and acetonitrile-water in various volume fractions. In order to explore and visualize similarities and differences among the investigated compounds and chromatographic system, Principal Component Analysis (PCA) was used. Results show that the experimental lipophllicity indices estimated from retention data (R-m,R-w, log k(w)) and PC1 are directly correlated with logP values at a high significant statistical level.

引用

页码：1 / 6

页数：6

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