Regulatory T Cells Move in When Gliomas Say "I DO"

被引：12
|
作者：
Choi, Bryan D. [1 ]
Fecci, Peter E. [2 ]
Sampson, John H. [1 ]
机构：
[1] Duke Univ, Preston Robert Tisch Brain Tumor Ctr, Duke Brain Tumor Immunotherapy Program, Div Neurosurg,Dept Surg,Med Ctr, Durham, NC 27710 USA
[2] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
来源：
CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 22期
关键词：
BRAIN-TUMORS; CTLA-4; BLOCKADE; COMPARTMENT; SURVIVAL; IMMUNITY;
D O I：
10.1158/1078-0432.CCR-12-2801
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great. Clin Cancer Res; 18(22); 6086-8. (C)2012 AACR.
引用
收藏
页码：6086 / 6088
页数：3
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