Regulatory T Cells Move in When Gliomas Say "I DO"

被引：12

作者：

Choi, Bryan D. ^{[1
]}

Fecci, Peter E. ^{[2
]}

Sampson, John H. ^{[1
]}

机构：

[1] Duke Univ, Preston Robert Tisch Brain Tumor Ctr, Duke Brain Tumor Immunotherapy Program, Div Neurosurg,Dept Surg,Med Ctr, Durham, NC 27710 USA

[2] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

来源：

CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 22期

关键词：

BRAIN-TUMORS; CTLA-4; BLOCKADE; COMPARTMENT; SURVIVAL; IMMUNITY;

D O I：

10.1158/1078-0432.CCR-12-2801

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great. Clin Cancer Res; 18(22); 6086-8. (C)2012 AACR.

引用

下载

页码：6086 / 6088

页数：3

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