Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

被引：7

作者：

Smith, Robert W. ^{[1
]}

Reynolds, James C. ^{[1
]}

Lee, Sze-Ling ^{[1
]}

Creaser, Colin S. ^{[1
]}

机构：

[1] Univ Loughborough, Dept Chem, Ctr Analyt Sci, Loughborough LE11 3TU, Leics, England

来源：

ANALYTICAL METHODS | 2013年 / 5卷 / 16期

关键词：

VOLATILE ORGANIC-COMPOUNDS;

D O I：

10.1039/c3ay40676h

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMS-selected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.

引用

页码：3799 / 3802

页数：4

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