Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry

被引：7
|
作者：
Smith, Robert W. [1 ]
Reynolds, James C. [1 ]
Lee, Sze-Ling [1 ]
Creaser, Colin S. [1 ]
机构：
[1] Univ Loughborough, Dept Chem, Ctr Analyt Sci, Loughborough LE11 3TU, Leics, England
来源：
ANALYTICAL METHODS | 2013年 / 5卷 / 16期
关键词：
VOLATILE ORGANIC-COMPOUNDS;
D O I：
10.1039/c3ay40676h
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMS-selected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.
引用
收藏
页码：3799 / 3802
页数：4
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