Determination of the Mechanical Properties of Model Lipid Bilayers Using Atomic Force Microscopy Indentation

被引：9

作者：

Drabik, Dominik ^{[1
]}

Gavutis, Martynas ^{[2
]}

Valiokas, Ramunas ^{[2
]}

Ulcinas, Arturas ^{[2
]}

机构：

[1] Univ Wroclaw, Fac Biotechnol, Lab Cytobiochem, PL-50383 Wroclaw, Poland

[2] Ctr Phys Sci & Technol, Dept Nanoengn, LT-02300 Vilnius, Lithuania

来源：

LANGMUIR | 2020年 / 36卷 / 44期

关键词：

Lipid bilayers - Deformation;

D O I：

10.1021/acs.langmuir.0c02181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By conducting a systematic study of model lipid membranes using the atomic force microscopy (AFM) indentation, we demonstrate the importance of an experimental protocol on the determination of their mechanical parameters. We refine the experimental approach by analyzing the influence of the contact mechanics models used to process the data, substrate preparation, and indenter geometry. We show that both bending rigidity and area compressibility can be determined from a single AFM indentation measurement.

引用

页码：13251 / 13262

页数：12

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