Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar

被引：9
|
作者：
Williams, Russell B.
Norris, Andrew
Miller, James S.
Razafitsalama, L. Jeremie
Andriantsiferana, Rabodo
Rasamison, Vincent E.
Kingston, David G. I. [1 ]
机构：
[1] Virginia Polytech Inst & State Univ, Dept Chem MC 0212, Blacksburg, VA 24061 USA
[2] Missouri Bot Garden, St Louis, MO 63166 USA
[3] Ctr Natl Applicat Rech Pharmaceut, Antananarivo, Madagascar
来源：
PLANTA MEDICA | 2006年 / 72卷 / 06期
关键词：
D O I：
10.1055/s-2006-931554
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-guided fractionation of the root and stem extracts of Mendoncia cowanii led to the isolation of two new and two known naphthoquinones. The structures of the new compounds, avicequinones D and E (11 and 2), were determined using I D and 2D NMR spectroscopy and by chemical conversion of compound 1 to 2. The new compounds were active in the A2780 human ovarian cancer cell line with IC50 values of 7.4-50 mu M, respectively, and 1, 3, and 4 were subsequently found to be weakly active in an assay for inhibition of the kinase Akt.
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页码：564 / 566
页数：3
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