Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar

被引：9

作者：

Williams, Russell B.

Norris, Andrew

Miller, James S.

Razafitsalama, L. Jeremie

Andriantsiferana, Rabodo

Rasamison, Vincent E.

Kingston, David G. I. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem MC 0212, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Ctr Natl Applicat Rech Pharmaceut, Antananarivo, Madagascar

来源：

PLANTA MEDICA | 2006年 / 72卷 / 06期

关键词：

D O I：

10.1055/s-2006-931554

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the root and stem extracts of Mendoncia cowanii led to the isolation of two new and two known naphthoquinones. The structures of the new compounds, avicequinones D and E (11 and 2), were determined using I D and 2D NMR spectroscopy and by chemical conversion of compound 1 to 2. The new compounds were active in the A2780 human ovarian cancer cell line with IC50 values of 7.4-50 mu M, respectively, and 1, 3, and 4 were subsequently found to be weakly active in an assay for inhibition of the kinase Akt.

引用

页码：564 / 566

页数：3

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