Mechanistic studies of AV370, a potent FGFR3 antagonistic antibody

被引:0
|
作者
Bai, Ailin [1 ]
Winston, William [1 ]
Meetze, Kristan [1 ]
Kollipara, Sriram [1 ]
Woo, Jin-Kyeung [1 ]
Nhi Vo [1 ]
Kosmatka, Monica [1 ]
Breault, Lyne [1 ]
Weiler, Solly [1 ]
Kabbarah, Omar [1 ]
Boudrow, Andrea [1 ]
Connolly, Kelly [1 ]
DiPrima, Michael [1 ]
Tissire, Hamid [1 ]
Jiang, Jinwei [1 ]
Gyuris, Jeno [1 ]
Weng, Zhigang [1 ]
机构
[1] AVEO Pharmaceut Inc, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3775
引用
收藏
页数:2
相关论文
共 38 条
  • [31] Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma
    Kamath, Amrita V.
    Lu, Dan
    Gupta, Priyanka
    Jin, Denise
    Xin, Yan
    Brady, Ann
    Stephan, Jean-Philippe
    Li, Hao
    Tien, Janet
    Qing, Jing
    Damico-Beyer, Lisa A.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (04) : 1071 - 1078
  • [32] A Phase I Dose-escalation Study of MFGR1877S, a Human Monoclonal Anti-fibroblast Growth Factor Receptor 3 (FGFR3) Antibody, in Patients (pts) with Advanced Solid Tumors
    ODonnell, P.
    Goldman, J. W.
    Gordon, M. S.
    Shih, K.
    Choi, Y. J.
    Lu, D.
    Kabbarah, O.
    Ho, W.
    Rooney, I.
    Lam, E. T.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : 191 - 192
  • [33] A Phase I Study of the Safety and Pharmacokinetics of Escalating Doses of MFGR1877S, a Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody, in Patients with Relapsed or Refractory t(4;14)-Positive Multiple Myeloma
    Trudel, Suzanne
    Bergsagel, P. Leif
    Singhal, Seema
    Niesvizky, Ruben
    Comenzo, Raymond L.
    Bensinger, William I.
    Lebovic, Daniel
    Choi, YounJeong
    Lu, Dan
    French, Dorothy
    Penuel, Elicia
    Ho, William
    Stewart, Keith
    BLOOD, 2012, 120 (21)
  • [34] 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies
    Di Pietro, Ornella
    Viayna, Elisabet
    Vicente-Garcia, Esther
    Bartolini, Manuela
    Ramon, Rosario
    Juarez-Jimenez, Jordi
    Victoria Clos, M.
    Perez, Belen
    Andrisano, Vincenza
    Javier Luque, F.
    Lavilla, Rodolfo
    Munoz-Torrero, Diego
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 73 : 141 - 152
  • [35] MRG006A, a novel glypican-3-targeting antibody-drug conjugate, demonstrated potent anti-tumor activity and good safety profile in preclinical studies
    Wang, Yanchun
    Li, Hongfeng
    Shen, Hao
    Liu, Wenchao
    Liu, Shoujia
    Yin, Kequan
    Xu, Haili
    Cui, Xueyuan
    Li, Wei
    Liu, Wei
    Wu, Xiangyu
    Yang, Liu
    Ma, Tian
    Zhao, Zhongrun
    Wang, Jun
    Cui, Feifei
    Fang, Lei
    Qin, Minmin
    Hu, Chaohong
    CANCER RESEARCH, 2024, 84 (06)
  • [36] Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl) furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies
    Dige, Nilam C.
    Mahajan, Prasad G.
    Raza, Hussain
    Hassan, Mubashir
    Vanjare, Balasaheb D.
    Hong, Hansol
    Lee, Ki Hwan
    Latip, Jalifah
    Seo, Sung-Yum
    BIOORGANIC CHEMISTRY, 2019, 92
  • [37] Synthetic studies on himbacine, a potent antagonist of the muscarinic M2 subtype receptor.: Part 2:: Synthesis and muscarinic M2 subtype antagonistic activity of the novel himbacine congeners modified at the C-3 position of lactone moiety
    Takadoi, M
    Yamaguchi, K
    Terashima, S
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (07) : 1169 - 1186
  • [38] Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
    Huang, Huoming
    Li, Xueping
    Xie, Peng
    Li, Xinwei
    Xu, XueJun
    Qian, Yuanyuan
    Yuan, Congmin
    Meng, Xiangguo
    Chai, JingRui
    Chen, Jing
    Liu, Jing
    Wang, Wenli
    Li, Wei
    Wang, YuJun
    Fu, Wei
    Liu, Jinggen
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (13) : 9458 - 9483