MRG006A, a novel glypican-3-targeting antibody-drug conjugate, demonstrated potent anti-tumor activity and good safety profile in preclinical studies

被引：0
|
作者：
Wang, Yanchun
Li, Hongfeng
Shen, Hao
Liu, Wenchao
Liu, Shoujia
Yin, Kequan
Xu, Haili
Cui, Xueyuan
Li, Wei
Liu, Wei
Wu, Xiangyu
Yang, Liu
Ma, Tian
Zhao, Zhongrun
Wang, Jun
Cui, Feifei
Fang, Lei
Qin, Minmin
Hu, Chaohong
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-3124
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3124
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Tumor targeting of a STING agonist with an antibody-drug conjugate elicits potent anti-tumor immune responses
    Cetinbas, Naniye Malli
    Catcott, Kalli
    Avocetien, Kenneth
    Bentley, Keith
    Carter, Tyler
    Chin, Chen-Ni
    Clardy, Susan
    Eitas, Timothy
    Jones, Brian
    Kelleher, Eoin
    Mosher, Rebecca
    Nazzaro, Mark
    Nehilla, Barrett
    Protopopova, Marina
    Shaw, Pamela
    Slocum, Kelly
    Qin, LiuLiang
    Thomas, Josh
    Yang, Liping
    Toader, Dorin
    Damelin, Marc
    Duvall, Jeremy
    Bukhalid, Raghida
    Lowinger, Timothy
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [2] ZW251, a novel glypican-3-targeting antibody-drug conjugate bearing a topoisomerase I inhibitor payload demonstrates compelling preclinical activity in hepatocellular carcinoma models
    Madera, L.
    Wu, A.
    Bissessur, A.
    Chan, A.
    Cheng, C. W.
    Yin, K.
    Alonzo, D. A.
    Tsui, J.
    Sim, D.
    Wu, K.
    Urosev, D.
    Petersen, M. E.
    Hershberger, S.
    Stahl, K.
    Rojas, A. Hernandez
    Fung, V.
    Colombo, R.
    Barnscher, S. D.
    Rich, J. R.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S70 - S70
  • [3] Novel CDH17-targeting antibody-drug conjugate exhibits anti-tumor efficacy in preclinical models of gastrointestinal cancers
    Wong, Po Yee
    He, Lin
    Chow, Kronos
    Wong, Kwan Wa
    O, Chui Yee
    Wong, Dennis
    Luk, John Moon
    Lo, Pui-Chi
    Wong, Kwong Fai
    CANCER RESEARCH, 2024, 84 (06)
  • [4] Novel conditionally active biologic anti-Axl antibody-drug conjugate demonstrates anti-tumor efficacy and improved safety profile
    Chang, Cathy
    Frey, Gerhard
    Boyle, William J.
    Sharp, Leslie L.
    Short, Jay M.
    CANCER RESEARCH, 2016, 76
  • [5] A novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5 has potent anti-tumor activity in colorectal cancer models
    Baudat, Yves
    Neff-LaFord, Haley
    Nicolazzi, Celine
    Meyer, Dave
    Sigurjonsson, Johann Petur
    Lyski, Ryan
    Fantin, Valeria
    Brun, Marie-Priscille
    Chiron, Marielle
    Decary, Stephanie
    CANCER RESEARCH, 2023, 83 (07)
  • [6] HMA800067, a novel CD38-targeting antibody-drug conjugate (ADC), demonstrated superior anti-tumor activity to daratumumab in preclinical B-cell malignancies models
    Xu, Yan
    Liang, Junqing
    Jiang, Shuwen
    Yang, Haibin
    Zhang, Hui
    Mao, Fangfang
    Zhu, Jiahuan
    He, Jianlin
    Yang, Na
    Wang, Jian
    Zhang, WeiHan
    Ren, Yongxin
    Su, Weiguo
    CANCER RESEARCH, 2024, 84 (06)
  • [7] Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer
    Matsuzaki, Satoko
    Serada, Satoshi
    Hiramatsu, Kosuke
    Nojima, Satoshi
    Matsuzaki, Shinya
    Ueda, Yutaka
    Ohkawara, Tomoharu
    Mabuchi, Seiji
    Fujimoto, Minoru
    Morii, Eiichi
    Yoshino, Kiyoshi
    Kimura, Tadashi
    Naka, Tetsuji
    INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (05) : 1056 - 1066
  • [8] A novel dual drug antibody-drug conjugate targeting hTrop2 has synergetic anti-tumor activity by enhancing systemic immunity
    Zhu, Jie
    Zhao, Xiaobei
    Luo, Zhenwu
    Li, Eileen
    Xu, Hong
    Wu, Cindy
    Chen, Gang
    Nie, Lei
    Wang, Haibin
    CANCER IMMUNOLOGY RESEARCH, 2025, 13 (02)
  • [9] Novel Globo H targeting antibody-drug conjugate with binding specificity and anti-tumor efficacy in multiple cancer types
    Yang, Ming-Chen
    Chen, Yu-Jung
    Shia, Chi-Sheng
    Chang, Hui-Wen
    Li, Wan-Fen
    Yu, Cheng-Der Tony
    Chen, I-Ju
    CANCER RESEARCH, 2019, 79 (13)
  • [10] Potent anti-tumor activity of T-DM1 antibody-drug conjugate in combination with chemotherapeutic agents in breast tumor cells
    Parsons, K.
    Fields, C.
    Gunter, B.
    Phillips, G.
    Tibbitts, J.
    EJC SUPPLEMENTS, 2010, 8 (07): : 35 - 35
12345