MRG006A, a novel glypican-3-targeting antibody-drug conjugate, demonstrated potent anti-tumor activity and good safety profile in preclinical studies

被引：0
|
作者：
Wang, Yanchun
Li, Hongfeng
Shen, Hao
Liu, Wenchao
Liu, Shoujia
Yin, Kequan
Xu, Haili
Cui, Xueyuan
Li, Wei
Liu, Wei
Wu, Xiangyu
Yang, Liu
Ma, Tian
Zhao, Zhongrun
Wang, Jun
Cui, Feifei
Fang, Lei
Qin, Minmin
Hu, Chaohong
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-3124
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3124
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Combining IMGN779, a Novel Anti-CD33 Antibody-Drug Conjugate (ADC), with the PARP Inhibitor, Olaparib, Results in Enhanced Anti-Tumor Activity in Preclinical Acute Myeloid Leukemia (AML) Models
    Portwood, Scott
    Puchalski, Robert A.
    Walker, Russell M.
    Wang, Eunice S.
    BLOOD, 2016, 128 (22)
  • [32] SGN-CEACAM5C/SAR445953, a novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5, has potent anti-tumor activity in CRC, PDAC, GC and lung cancer tumor models
    Baudat, Yves
    Nicolazzi, Celine
    Sigurjonsson, Johann Petur
    Amara, Celine
    Clarke, Astrid
    Lyski, Ryan
    Meyer, Dave
    Fantin, Valeria
    Chiron, Marielle
    Decary, Stephanie
    CANCER RESEARCH, 2024, 84 (06)
  • [33] PRO1184, a novel folate receptor alpha-directed antibody-drug conjugate, demonstrates robust anti-tumor activity in mouse carcinoma models
    Zhao, Baiteng
    Wang, Lei
    Liu, Haidong
    Huang, Suping
    Shang, Xiao
    Han, Tae
    CANCER RESEARCH, 2022, 82 (12)
  • [34] SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models
    Chang-yong Yang
    Lei Wang
    Xing Sun
    Mi Tang
    Hai-tian Quan
    Lian-shan Zhang
    Li-guang Lou
    Shao-hua Gou
    Acta Pharmacologica Sinica, 2019, 40 : 971 - 979
  • [35] SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models
    Yang, Chang-yong
    Wang, Lei
    Sun, Xing
    Tang, Mi
    Quan, Hai-tian
    Zhang, Lian-shan
    Lou, Li-guang
    Gou, Shao-hua
    ACTA PHARMACOLOGICA SINICA, 2019, 40 (07) : 971 - 979
  • [36] DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer
    Xi Li
    Liwen Liang
    Zhongyuan Zhu
    Haiqing Hua
    Yang Qiu
    Cancer Biology & Medicine, 2025, 22 (03) : 231 - 236
  • [37] DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2and HER3-expressing breast cancer
    Li, Xi
    Liang, Liwen
    Zhu, Zhongyuan
    Hua, Haiqing
    Qiu, Yang
    CANCER BIOLOGY & MEDICINE, 2025,
  • [38] FZ-AD005, a Novel DLL3-Targeted Antibody-Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models
    Guo, Qingsong
    Gao, Bei
    Song, Ruiwen
    Li, Weinan
    Zhu, Shulei
    Xie, Qian
    Lou, Sensen
    Wang, Lei
    Shen, Jiafei
    Zhao, Teng
    Zhang, Yifan
    Wu, Jinsong
    Lu, Wei
    Yang, Tong
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (10) : 1367 - 1377
  • [39] AGS62P1, a novel site-specific antibody drug conjugate targeting FLT3 exhibits potent anti-tumor activity regardless of FLT3 kinase activation status
    Rudra-Ganguly, Nandini
    Challita-Eid, Pia M.
    Lowe, Christine
    Mattie, Mike
    Moon, Sung-Ju
    Mendelsohn, Brian A.
    Leavitt, Monica
    Virata, Cyrus
    Verlinsky, Alla
    Capo, Linnette
    Chang, Mi Soak
    Russell, Deanna L.
    Randhawa, Baljinder
    Liu, Gao
    Hubert, Rene
    Brodey, Mary
    Avina, Hector
    Zhang, Chunying
    Abad, Joseph D.
    Anand, Banmeet
    Karki, Sher
    An, Zili
    Luethy, Roland
    Donate, Fernando
    Pereira, Daniel S.
    Morrison, Kendall
    Joseph, Ingrid B. J.
    Stover, David R.
    CANCER RESEARCH, 2016, 76
  • [40] An AXL-specific antibody-drug conjugate shows preclinical anti-tumor activity in non-small cell lung cancer, including EGFR-inhibitor resistant NSCLC
    Koopman, Louise A.
    Janmaat, Maarten L.
    Jacobsen, Kirstine
    Terp, Mikkel Green
    Gresnigt-van den Heuvel, Elke
    Forssman, Ulf
    Lingnau, Andreas
    Parren, Paul W.
    Ditzel, Henrik
    Breij, Esther C.
    CANCER RESEARCH, 2018, 78 (13)
12345