Biomimetic and Cell-Mediated Mineralization of Hydroxyapatite by Carrageenan Functionalized Graphene Oxide

被引：125

作者：

Liu, Hongyan ^{[1
,2
]}

Cheng, Ju ^{[3
]}

Chen, Fengjuan ^{[1
,2
]}

Hou, Fengping ^{[1
,2
]}

Bai, Decheng ^{[3
]}

Xi, Pinxian ^{[1
,2
]}

Zeng, Zhengzhi ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Res Ctr Biomed Nanotechnol, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2014年 / 6卷 / 05期

关键词：

graphene oxide; carrageenan; hydroxyapatite; Biomimetic mineralization; cell-mediated; IN-VITRO; MECHANICAL-PROPERTIES; OSTEOBLASTIC CELLS; BONE; COMPOSITE; COLLAGEN; BIOMATERIALS; HYDROGELS; PROLIFERATION; SCAFFOLDS;

D O I：

10.1021/am4057826

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In bone tissue engineering, it is imperative to design multifunctional biomaterials that can induce and assemble bonelike apatite that is close to natural bone. In this study, graphene oxide (GO) was functionalized by carrageenan. The resulting GO-carrageenan (GO-Car) composite was further used as a substrate for biomimetic and cell-mediated mineralization of hydroxyapatite (HA). It was confirmed that carrageenan on the GO surface facilitated the nucleation of HA. The observation of the effect of the GO-Car on the adhesion, morphology, and proliferation of MC3T3-E1 cells was investigated. In vitro studies clearly show the effectiveness of GO-Car in promoting HA mineralization and cell differentiation. The results of this study suggested that the GO-Car hybrid will be a promising material for bone regeneration and implantation.

引用

页码：3132 / 3140

页数：9

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