In Vitro Study of Hydroxyapatite Coatings on Fibrin Functionalized/Pristine Graphene Oxide for Bone Grafting

被引：34

作者：

Deepachitra, Ramani ^{[1
]}

Nigam, Rashi ^{[2
]}

Purohit, Shiv Dutt ^{[3
]}

Kumar, Baskar Santhosh ^{[1
]}

Hemalatha, Thiagarajan ^{[1
]}

Sastry, Thotapalli P. ^{[1
]}

机构：

[1] Cent Leather Res Inst, Bioprod Lab, Chennai 600020, Tamil Nadu, India

[2] VIT Univ, Ctr Biomed Div, Vellore, Tamil Nadu, India

[3] Univ Rajasthan, Ctr Converging Technol, Jaipur 302004, Rajasthan, India

来源：

MATERIALS AND MANUFACTURING PROCESSES | 2015年 / 30卷 / 06期

关键词：

In situ; Hydroxyapatite; Fibrin; Biomedical; Functional; In vitro studies; Graphene oxide; Mechanical strength; Composites; Biomaterials; COMPOSITE SCAFFOLDS; OSTEOGENIC RESPONSE; CALCIUM-PHOSPHATE; CELLS; MINERALIZATION; NANOCOMPOSITES; MIXTURE; GROWTH; FEMUR; ASSAY;

D O I：

10.1080/10426914.2014.994758

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Fibrin functionalized graphene oxide (FGO) and graphene oxide (GO) were used as nucleation sites for the growth of hydroxyapatite (HA). The growth of HA on GO/FGO was done by wet precipitation method, and they were characterized for their physicochemical properties. Cytotoxicity was confirmed by reactive oxygen species assay and cell viability assay; alkaline phosphatase assay, alizarin red test, and protein expression studies showed that FGHA was an excellent composite for osteoblast cell growth and maturation. Alamar blue assay was used to study the enzymatically degraded cytocompatibility of enzymatically degraded components. Results proved that FGHA might be tried as an osteoinductive material, in orthopedic defects.

引用

页码：804 / 811

页数：8

共 50 条

[1] Fibrin hydrogel incorporated with graphene oxide functionalized nanocomposite scaffolds for bone repair - In vitro and in vivo study
Pathmanapan, Srinivetha
Periyathambi, Prabu
Anandasadagopan, Suresh Kumar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 29 (29)
[2] In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide
Li, Ming
Wang, Yanbo
Liu, Qian
Li, Qiuhong
Cheng, Yan
Zheng, Yufeng
Xi, Tingfei
Wei, Shicheng
JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (04) : 475 - 484
[3] Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation
Liu, Hongyan
Cheng, Ju
Chen, Fengjuan
Bai, Decheng
Shao, Changwei
Wang, Jun
Xi, Pinxian
Zeng, Zhengzhi
NANOSCALE, 2014, 6 (10) : 5315 - 5322
[4] Role of graphene oxide and functionalized graphene oxide in protective hybrid coatings
Airashed, Maher M.
Soucek, Mark D.
Jana, Sadhan C.
PROGRESS IN ORGANIC COATINGS, 2019, 134 : 197 - 208
[5] Corrosion study of silane-functionalized graphene oxide coatings on copper
Raza, Mohsin Ali
Rehman, Zaeem Ur
Ghauri, Faizan Ali
THIN SOLID FILMS, 2018, 663 : 93 - 99
[6] The chemistry and topography of stabilized and functionalized graphene oxide coatings
Awaja, Firas
Tripathi, Manoj
Wong, Tsz-Ting
O'Brien, Timothy
Speranza, Giorgio
PLASMA PROCESSES AND POLYMERS, 2018, 15 (10)
[7] Graphene oxide/hydroxyapatite composite coatings fabricated by electrochemical deposition
Zeng, Yongxiang
Pei, Xibo
Yang, Shuying
Qin, Han
Cai, He
Hu, Shanshan
Sui, Lei
Wan, Qianbing
Wang, Jian
SURFACE & COATINGS TECHNOLOGY, 2016, 286 : 72 - 79
[8] In vitro comparative study of pure hydroxyapatite nanorods and novel polyethylene glycol/graphene oxide/hydroxyapatite nanocomposite
Mohandes, Fatemeh
Salavati-Niasari, Masoud
JOURNAL OF NANOPARTICLE RESEARCH, 2014, 16 (09)
[9] Synthesis of Graphene Oxide/Hydroxyapatite Composite Coatings by Electrochemical Deposition
Zeng Yongxiang
He Rui
Pei Xibo
Tian Lingyang
Wang Jian
Wan Qianbing
RARE METAL MATERIALS AND ENGINEERING, 2016, 45 (03) : 727 - 731
[10] In vitro comparative study of pure hydroxyapatite nanorods and novel polyethylene glycol/graphene oxide/hydroxyapatite nanocomposite
Fatemeh Mohandes
Masoud Salavati-Niasari
Journal of Nanoparticle Research, 2014, 16

← 1 2 3 4 5 →