The EWS/FLI1 transcriptome is characterized by marked heterogeneity across Ewing sarcoma cell lines

被引:0
|
作者
Kitchen-Goosen, Susan M. [1 ]
Bowman, Megan J. [1 ]
Adams, Marie [1 ]
Berger, Penny [1 ]
Grohar, Patrick J. [1 ]
机构
[1] Van Andel Res Inst, Grand Rapids, MI USA
关键词
D O I
10.1158/1538-7445.AM2018-3356
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3356
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma
    Boro, Aleksandar
    Pretre, Kathya
    Rechfeld, Florian
    Thalhammer, Verena
    Oesch, Susanne
    Wachtel, Marco
    Schaefer, Beat W.
    Niggli, Felix K.
    INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (09) : 2153 - 2164
  • [32] Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors
    Desmaze, C
    Brizard, F
    TurcCarel, C
    Melot, T
    Delattre, O
    Thomas, G
    Aurias, A
    CANCER GENETICS AND CYTOGENETICS, 1997, 97 (01) : 12 - 19
  • [33] SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma
    Hughes, Connor J.
    Fields, Kaiah M.
    Danis, Etienne P.
    Hsu, Jessica Y.
    Neelakantan, Deepika
    Vincent, Melanie Y.
    Gustafson, Annika L.
    Oliphant, Michael J.
    Sreekanth, Varsha
    Zaberezhnyy, Vadym
    Costello, James C.
    Jedlicka, Paul
    Ford, Heide L.
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [34] EWS/FLI1 transcription is modulated by the PI3K pathway via SP1 in Ewing sarcoma
    Giorgi, Chiara
    Boro, Alexander
    Lopez-Garcia, Laura A.
    Schaefer, Beat W.
    Niggli, Felix K.
    CANCER RESEARCH, 2015, 75
  • [35] Absence of EWS/FLI1 fusion in olfactory neuroblastomas indicates these tumors do not belong to the Ewing's sarcoma family
    Kumar, S
    Perlman, E
    Pack, S
    Davis, M
    Zhang, H
    Meltzer, P
    Tsokos, M
    HUMAN PATHOLOGY, 1999, 30 (11) : 1356 - 1360
  • [36] SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma
    Connor J. Hughes
    Kaiah M. Fields
    Etienne P. Danis
    Jessica Y. Hsu
    Deepika Neelakantan
    Melanie Y. Vincent
    Annika L. Gustafson
    Michael J. Oliphant
    Varsha Sreekanth
    Vadym Zaberezhnyy
    James C. Costello
    Paul Jedlicka
    Heide L. Ford
    Nature Communications, 14
  • [37] Targeting the EWS-FLI1 transcription factor in Ewing sarcoma
    Tancredi, R.
    Zambelli, A.
    DaPrada, G. A.
    Fregoni, V.
    Pavesi, L.
    Riccardi, A.
    Burdach, S.
    Grohar, P. J.
    D'Incalci, M.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2015, 75 (06) : 1317 - 1320
  • [38] EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
    Aparna Gorthi
    July Carolina Romero
    Eva Loranc
    Lin Cao
    Liesl A. Lawrence
    Elicia Goodale
    Amanda Balboni Iniguez
    Xavier Bernard
    V. Pragathi Masamsetti
    Sydney Roston
    Elizabeth R. Lawlor
    Jeffrey A. Toretsky
    Kimberly Stegmaier
    Stephen L. Lessnick
    Yidong Chen
    Alexander J. R. Bishop
    Nature, 2018, 555 : 387 - 391
  • [39] Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma
    Suresh, Veveeyan
    Hafemeister, Christoph
    Grissenberger, Sarah
    Sturtzel, Caterina
    Aranaz, Florencia Cidre
    Grunewald, Thomas
    Sastre, Ana
    Alonso, Javier
    Distel, Martin
    Halbritter, Florian
    Kovar, Heinrich
    Fock, Valerie
    CANCER RESEARCH, 2024, 84 (17)
  • [40] Downstream EWS/FLI1-upstream Ewing's sarcoma
    Kovar, Heinrich
    GENOME MEDICINE, 2010, 2