Pro-inflammatory and pro-apoptotic properties of Human Defensin 5

被引：26

作者：

Lu, Wuyuan ^{[1
]}

de Leeuw, Erik ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 436卷 / 03期

关键词：

Human Defensin 5; Intestinal epithelium; Interleukin; 8; Antimicrobial peptide; Apoptosis; ALPHA-DEFENSINS; ANTIMICROBIAL PEPTIDES; CROHNS-DISEASE; ANTIBACTERIAL ACTIVITY; MAMMALIAN DEFENSINS; DENDRITIC CELLS; BETA-DEFENSINS; MAST-CELLS; SUSCEPTIBILITY; DEFICIENCY;

D O I：

10.1016/j.bbrc.2013.06.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defensins are cationic antimicrobial peptides that play an important role in innate immunity by primarily acting against microbes. Their antimicrobial properties have been widely studied and are well understood. Defensins contribute to regulation of host immunity also. Their effects on cells of the host however are less well understood. Here, we report on the pro-inflammatory and apoptotic properties of Human Defensin 5, the major antimicrobial peptide of ileal Paneth cells. We find that HD-5 up-regulates expression of genes involved in cell survival and inflammation in a NF-kB-dependent fashion in epithelial cells. Further, we find that HD-5 has pro-apoptotic effects on intestinal epithelial cells as well as primary CD4+ T cells. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

引用

页码：557 / 562

页数：6

共 50 条

[41] A Comparative Study of the Cytotoxic and Pro-apoptotic Properties of Nepeta binaloudensis
Emami, Seyed Ahmad
Al-Najjar, Hadi
Asili, Javad
Habibi, Maryam Sadat
Sahebkar, Amirhossein
Tayarani-Najaran, Zahra
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 16 (05) : 563 - 569
[42] Pro-Apoptotic and Pro-Autophagic Properties of Cardenolides from Aerial Parts of Pergularia tomentosa
Martucciello, Stefania
Paolella, Gaetana
Romanelli, Antonio Massimiliano
Sposito, Silvia
Meola, Lucia
Cerulli, Antonietta
Masullo, Milena
Piacente, Sonia
Caputo, Ivana
MOLECULES, 2022, 27 (15):
[43] Pro-inflammatory adhesins
Haskard, DO
VASCULAR ENDOTHELIUM: RESPONSES TO INJURY, 1996, 281 : 145 - 154
[44] Pro-inflammatory Prevotella?
Ursula Hofer
Nature Reviews Microbiology, 2014, 12 : 5 - 5
[45] Pro-inflammatory properties of shark cartilage supplement
Merly, Liza
Smith, Sylvia L.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2015, 37 (02) : 140 - 147
[46] Pro-inflammatory properties of aureocin A53
Smiaek-Bartyzel, Justyna
Bzowska, Monika
Mak, Pawe
MICROBES AND INFECTION, 2024, 26 (5-6)
[47] Pro-inflammatory Cytokines in Animal and Human Gestation
Paulesu, Luana
Bhattacharjee, Jayonta
Bechi, Nicoletta
Romagnoli, Roberta
Jantra, Silke
Ietta, Francesca
CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (32) : 3601 - 3615
[48] Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
Semple, Fiona
MacPherson, Heather
Webb, Sheila
Cox, Sarah L.
Mallin, Lucy J.
Tyrrell, Christine
Grimes, Graeme R.
Semple, Colin A.
Nix, Matthew A.
Millhauser, Glenn L.
Dorin, Julia R.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (11) : 3291 - 3300
[49] RIPs: An emerging family of kinases involved in pro-inflammatory and apoptotic signaling
Dixit, VM
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1999, 64 : 359 - 362
[50] Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats
Kim, Gyeong-Ji
Song, Da Hye
Yoo, Han Seok
Chung, Kang-Hyun
Lee, Kwon Jai
An, Jeung Hee
NUTRIENTS, 2017, 9 (01):

← 1 2 3 4 5 →