Pro-inflammatory and pro-apoptotic properties of Human Defensin 5

被引：26

作者：

Lu, Wuyuan ^{[1
]}

de Leeuw, Erik ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 436卷 / 03期

关键词：

Human Defensin 5; Intestinal epithelium; Interleukin; 8; Antimicrobial peptide; Apoptosis; ALPHA-DEFENSINS; ANTIMICROBIAL PEPTIDES; CROHNS-DISEASE; ANTIBACTERIAL ACTIVITY; MAMMALIAN DEFENSINS; DENDRITIC CELLS; BETA-DEFENSINS; MAST-CELLS; SUSCEPTIBILITY; DEFICIENCY;

D O I：

10.1016/j.bbrc.2013.06.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defensins are cationic antimicrobial peptides that play an important role in innate immunity by primarily acting against microbes. Their antimicrobial properties have been widely studied and are well understood. Defensins contribute to regulation of host immunity also. Their effects on cells of the host however are less well understood. Here, we report on the pro-inflammatory and apoptotic properties of Human Defensin 5, the major antimicrobial peptide of ileal Paneth cells. We find that HD-5 up-regulates expression of genes involved in cell survival and inflammation in a NF-kB-dependent fashion in epithelial cells. Further, we find that HD-5 has pro-apoptotic effects on intestinal epithelial cells as well as primary CD4+ T cells. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

引用

页码：557 / 562

页数：6

共 50 条

[11] Pro-inflammatory sebocyte growth and survival signalling in acne vulgaris are reversed by pro-apoptotic isotretinoin signalling
Melnik, Bodo C.
EXPERIMENTAL DERMATOLOGY, 2016, 25 (09) : 676 - 677
[12] SO2 inhalation modulates the expression of pro-inflammatory and pro-apoptotic genes in rat heart and lung
Yun, Yang
Hou, Li
Sang, Nan
JOURNAL OF HAZARDOUS MATERIALS, 2011, 185 (01) : 482 - 488
[13] Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery
Gesa Cohrs
Bea Drucks
Jan-Philip Sürie
Christian Vokuhl
Michael Synowitz
Janka Held-Feindt
Friederike Knerlich-Lukoschus
Child's Nervous System, 2019, 35 : 315 - 328
[14] Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery
Cohrs, Gesa
Drucks, Bea
Suerie, Jan-Philip
Vokuhl, Christian
Synowitz, Michael
Held-Feindt, Janka
Knerlich-Lukoschus, Friederike
CHILDS NERVOUS SYSTEM, 2019, 35 (02) : 315 - 328
[15] Defibrotide protects human microvascular endothelial cells from fludarabine-mediated pro-inflammatory and pro-apoptotic signals: a microarray (Affimetrix) analysis
Echart, C.
Eissner, G.
Holler, E.
Iacobelli, M.
BONE MARROW TRANSPLANTATION, 2010, 45 : S281 - S281
[16] Pro-apoptotic agents
Stahel, Rolf A.
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S21 - S21
[17] Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells
Heutinck, Kirstin M.
Rowshani, Ajda T.
Kassies, Jorien
Claessen, Nike
van Donselaar-van der Pant, Karlijn A. M. I.
Bemelman, Frederike J.
Eldering, Eric
van Lier, Rene A. W.
Florquin, Sandrine
ten Berge, Ineke J. M.
Hamann, Jorg
KIDNEY INTERNATIONAL, 2012, 82 (06) : 664 - 675
[18] Pro-inflammatory properties of cadmium
Olszowski, Tomasz
Baranowska-Bosiacka, Irena
Gutowska, Izabela
Chlubek, Dariusz
ACTA BIOCHIMICA POLONICA, 2012, 59 (04) : 475 - 482
[19] Pro-inflammatory properties for thiazolidinediones
Desmet, C
Warzée, B
Gosset, P
Mélotte, D
Rongvaux, A
Gillet, L
Fiévez, L
Seumois, G
Vanderplasschen, A
Staels, B
Lekeux, P
Bureau, F
BIOCHEMICAL PHARMACOLOGY, 2005, 69 (02) : 255 - 265
[20] Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis
Leal, R. F.
Coy, C. S. R.
Ayrizono, M. L. S.
Fagundes, J. J.
Milanski, M.
Saad, M. J.
Velloso, L. A.
Goes, J. R. N.
TECHNIQUES IN COLOPROCTOLOGY, 2008, 12 (01) : 33 - 38

← 1 2 3 4 5 →