Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19-Depleted Stem Cell Transplantation

被引：3

作者：

Goessling, Katharina L. ^{[1
]}

Fouz, Hiba ^{[1
]}

Kyrillopoulou, Olga ^{[1
]}

Aubin, Matthias ^{[1
]}

Maecker-Kolhoff, Britta ^{[2
]}

Adams, Ortwin ^{[3
]}

Borkhardt, Arndt ^{[1
]}

Babor, Florian ^{[1
]}

Schuster, Friedhelm R. ^{[1
]}

Siepermann, Meinolf ^{[1
]}

Schumm, Michael ^{[4
]}

Lang, Peter ^{[4
]}

Eiz-Vesper, Britta ^{[5
]}

Meisel, Roland ^{[1
]}

机构：

[1] Heinrich Heine Univ, Fac Med, Div Pediat Stem Cell Therapy, Clin Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany

[2] Hannover Med Sch, Dept Pediat Hematol & Oncol, Dusseldorf, Germany

[3] Heinrich Heine Univ, Inst Virol, Dusseldorf, Germany

[4] Univ Hosp Tubingen, Childrens Hosp, Tubingen, Germany

[5] Hannover Med Sch, Inst Transfus Med, Hannover, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 08期

关键词：

adenovirus; adenoviremia; haploidentical stem cell transplantation; adoptive T-cell transfer; adenovirus-specific T cells; INFECTION; CHILDREN; HSCT;

D O I：

10.1093/cid/ciy820

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, we report the case of severe adenoviremia in a 7-yearold boy with highly-resistant, acute leukemia. A combined approach of alpha beta TCR-CD19-depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.

引用

页码：1406 / 1409

页数：4

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