Viral-specific T-cell response in hemorrhagic cystitis after haploidentical donor stem cell transplantation

被引：8
|
作者：
Apiwattanakul, Nopporn [1 ]
Hongeng, Suradej [1 ]
Anurathapan, Usanarat [1 ]
Pakakasama, Samart [1 ]
Srisala, Supanart [2 ]
Techasaensiri, Chonnamet [1 ]
Andersson, Borje S. [3 ]
机构：
[1] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat, Bangkok, Thailand
[2] Mahidol Univ, Ramathibodi Hosp, Fac Med, Sect Res Ctr, Bangkok, Thailand
[3] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Stem Cell Transplantat, Houston, TX 77030 USA
来源：
TRANSPLANT INFECTIOUS DISEASE | 2017年 / 19卷 / 06期
关键词：
pediatric; post-transplant hemorrhagic cystitis; stem cell transplantation; viral-specific T cells; BK VIRUS-INFECTION; LOW-DOSE CIDOFOVIR; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; HEMATOLOGIC MALIGNANCIES; RECIPIENTS; IMMUNOPATHOLOGY; CLEARANCE; IMMUNITY; CHILDREN; SURVIVAL;
D O I：
10.1111/tid.12775
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Viral hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT) can be devastating. Standard treatment modalities have not been well established, but immune reconstitution may be necessary for sustained viral clearance. We studied five pediatric patients who developed viral HC after haplo-identical HSCT. All patients developed virus-specific CD4- and CD8-positive T cells, and the emergence of these viral-specific T cells was temporally associated with successful viral clearance.
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页数：7
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