A small-molecule thrombin receptor (PAR-1) antagonist blocks thrombosis in non-human primates.

被引:0
|
作者
Andrade-Gordon, P
Derian, CK
Damiano, BP
D'Andrea, MR
Addo, MF
Darrow, AL
Nedelman, M
Zhang, HC
Maryanoff, BE
机构
[1] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA
[2] Primedica Corp, Worcester, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
175
引用
收藏
页码:44A / 44A
页数:1
相关论文
共 50 条
  • [21] Beta-defensin 1 gene variability among non-human primates.
    Crovella, S
    Boniotto, M
    Del Pero, M
    Amoroso, A
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) : 355 - 355
  • [22] Molecular evolution of MC1R gene in human and non-human primates.
    Lu, XM
    Zhang, YP
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) : 355 - 355
  • [23] Release of the thrombin receptor (PAR-1) N-terminus from the surface of human platelets activated by thrombin
    Ramachandran, R
    Klufas, AS
    Molino, M
    Ahuja, M
    Hoxie, JA
    Brass, LF
    THROMBOSIS AND HAEMOSTASIS, 1997, 78 (03) : 1119 - 1124
  • [24] A small-molecule antagonist of human and murine CCR1 receptors
    Fernandez-Botran, R
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (07) : 1387 - 1389
  • [25] Discovery and optimization of potent orally active small molecular thrombin receptor PAR-1 antagonists.
    Kawahara, T
    Suzuki, S
    Kogushi, M
    Matsuoka, T
    Kobayashi, H
    Kajiwara, A
    Hishinuma, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U215 - U215
  • [26] Discovery and optimization of potent orally active small molecular thrombin receptor(PAR-1) antagonists.
    Kawahara, T
    Suzuki, S
    Matsuura, F
    Clark, RSJ
    Kogushi, M
    Kobayashi, H
    Hishinuma, L
    Sato, N
    Terauchi, T
    Kajiwara, A
    Matsuoka, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U21 - U21
  • [27] Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates (vol 304, pg 855, 2003)
    Derian, CK
    Damiano, BP
    Addo, MF
    Darrow, AL
    D'Andrea, MR
    Nedelman, M
    Zhang, HC
    Maryanoff, BE
    Andrade-Gordon, P
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 305 (01): : 402 - 402
  • [28] Pre-clinical assessment of genz-29155, a novel small molecule inhibitor of apoptosis with anti-rejection effects in non-human primates.
    Weaver, Timothy A.
    Charafeddine, Ali H.
    Leopardi, Frank V.
    Agarwal, Avinash
    Batty, Scott D.
    Williams, John M.
    Nahil, Sharon R.
    Kirk, Allan D.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 : 229 - 229
  • [29] IL4R Polymorphisms Are Associated with Response to IL4/IL13 Receptor Antagonist (Aerovant) in Human Asthmatics and Non-Human Primates.
    Slager, R. E.
    Diallo, A.
    Hawkins, G. A.
    Bowden, A.
    Stevens, L.
    Morton, M.
    Tomkinson, A.
    Longphre, M.
    Bleecker, E. R.
    Meyers, D. A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [30] PHARMACOKINETIC MODELING OF RDC-0313, A NOVEL OPIOID RECEPTOR ANTAGONIST, IN NON-HUMAN PRIMATES
    Li, W.
    Turncliff, R.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 : S60 - S61