Discovery and optimization of potent orally active small molecular thrombin receptor(PAR-1) antagonists.

被引:0
|
作者
Kawahara, T
Suzuki, S
Matsuura, F
Clark, RSJ
Kogushi, M
Kobayashi, H
Hishinuma, L
Sato, N
Terauchi, T
Kajiwara, A
Matsuoka, T
机构
[1] Eisai & Co Ltd, Frontier Res Labs, Tsukuba, Ibaraki 3002635, Japan
[2] Eisai & Co Ltd, Discovery Res Lab 1, Tsukuba, Ibaraki 3002635, Japan
[3] Eisai & Co Ltd, Marketed Prod Res Clin Res Ctr, Tsukuba, Ibaraki 3002635, Japan
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
085-MEDI
引用
收藏
页码:U21 / U21
页数:1
相关论文
共 50 条
  • [1] Discovery and optimization of potent orally active small molecular thrombin receptor PAR-1 antagonists.
    Kawahara, T
    Suzuki, S
    Kogushi, M
    Matsuoka, T
    Kobayashi, H
    Kajiwara, A
    Hishinuma, I
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U215 - U215
  • [2] Novel indole-based peptidomimetics as potent thrombin receptor (PAR-1) antagonists.
    Zhang, HC
    Hoekstra, WJ
    Maryanoff, BE
    McComsey, DF
    Poulter, BL
    White, KB
    Addo, MF
    Andrade-Gordon, P
    Derian, CK
    Oksenberg, D
    Reynolds, EE
    Scarborough, RM
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U910 - U910
  • [3] Discovery of potent, non-peptide thrombin receptor antagonists.
    Chackalamannil, S
    Xia, Y
    Clasby, M
    Greenlee, W
    Doller, D
    Eagen, K
    Tsai, HS
    Asberom, T
    Lin, Y
    Czarniecki, M
    Ahn, HS
    Foster, C
    Boykow, G
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U60 - U60
  • [4] Biphenylsulfonamide endothelin a receptor antagonists: Discovery and SAR of potent, selective and orally active second generation antagonists.
    Murugesan, N
    Gu, ZX
    Spergel, S
    Young, M
    Chen, P
    Liu, ECK
    Zhang, RG
    Marino, A
    Morrison, RA
    Webb, ML
    Moreland, S
    Barrish, JC
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : A108 - A108
  • [5] Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates
    Zhang, HC
    Derian, CK
    Andrade-Gordon, P
    Hoekstra, WJ
    McComsey, DF
    White, KB
    Poulter, BL
    Addo, MF
    Cheung, WM
    Damiano, BP
    Oksenberg, D
    Reynolds, EE
    Pandey, A
    Scarborough, RM
    Maryanoff, BE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (07) : 1021 - 1024
  • [6] Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif
    Hoekstra, WJ
    Hulshizer, BL
    McComsey, DF
    Andrade-Gordon, P
    Kauffman, JA
    Addo, MF
    Oksenberg, D
    Scarborough, RM
    Maryanoff, BE
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (13) : 1649 - 1654
  • [7] Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
    Chackalamannil, S
    Xia, Y
    Greenlee, WJ
    Clasby, M
    Doller, D
    Tsai, H
    Asberom, T
    Czarniecki, M
    Ahn, HS
    Boykow, G
    Foster, C
    Agans-Fantuzzi, J
    Bryant, M
    Lau, J
    Chintala, M
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (19) : 5884 - 5887
  • [8] Potent, selective, orally active, nonpeptide vasopressin receptor antagonists.
    Matthews, JM
    Dyatkin, AB
    Hecker, L
    Hlasta, DJ
    Hoekstra, WJ
    Poulter, B
    Andrade-Gordon, P
    de Garavilla, L
    Demarest, K
    Ericson, E
    Gunnet, J
    Hagman, W
    Look, R
    Moore, J
    Reynolds, CH
    Maryanoff, BE
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U913 - U914
  • [9] Discovery of orally active vitronectin receptor (αvβ3) antagonists.
    Heerding, DA
    Miller, WH
    Willette, R
    Yue, TL
    Lark, M
    Stroup, G
    Badger, A
    Ohlstein, E
    Gowen, M
    Huffman, WF
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U567 - U568
  • [10] Design and synthesis of potent and selective, orally active NK1 receptor antagonists.
    Stadler, H
    Boes, M
    Ballard, TM
    Galley, G
    Godel, T
    Higgins, GA
    Hoffmann, T
    Hunkeler, W
    Poli, SM
    Schnider, P
    Sleight, AJ
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U33 - U33