Discovery of orally active vitronectin receptor (αvβ3) antagonists.

被引：0
|
作者：
Heerding, DA
Miller, WH
Willette, R
Yue, TL
Lark, M
Stroup, G
Badger, A
Ohlstein, E
Gowen, M
Huffman, WF
机构：
[1] SmithKline Beecham Pharmaceut, Med Chem, Collegeville, PA 19426 USA
[2] SmithKline Beecham Pharmaceut, Cardiovasc Biol, Collegeville, PA USA
[3] SmithKline Beecham Pharmaceut, Bone & Cartilage Biol, Collegeville, PA USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 220卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
175-MEDI
引用
收藏
页码：U567 / U568
页数：2
相关论文
共 50 条
  • [1] Orally active, nonpeptide vitronectin receptor (αvβ3) antagonists.
    Miller, WH
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U861 - U861
  • [2] Orally active, nonpeptide vitronectin receptor (αvβ3) antagonists in angiogenesis.
    Samanen, JM
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U920 - U921
  • [3] Biphenylsulfonamide endothelin a receptor antagonists: Discovery and SAR of potent, selective and orally active second generation antagonists.
    Murugesan, N
    Gu, ZX
    Spergel, S
    Young, M
    Chen, P
    Liu, ECK
    Zhang, RG
    Marino, A
    Morrison, RA
    Webb, ML
    Moreland, S
    Barrish, JC
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : A108 - A108
  • [4] Discovery of potent αVβ3 antagonists.
    Jadhav, PK
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U568 - U568
  • [5] Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
    Miller, WH
    Manley, PJ
    Cousins, RD
    Erhard, KF
    Heerding, DA
    Kwon, C
    Ross, ST
    Samanen, JM
    Takata, DT
    Uzinskas, IN
    Yuan, CCK
    Haltiwanger, RC
    Gress, CJ
    Lark, MW
    Hwang, SM
    James, IE
    Rieman, DJ
    Willette, RN
    Yue, TL
    Azzarano, LM
    Salyers, KL
    Smith, BR
    Ward, KW
    Johanson, KO
    Huffman, WF
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (08) : 1483 - 1486
  • [6] Potent, selective, orally active, nonpeptide vasopressin receptor antagonists.
    Matthews, JM
    Dyatkin, AB
    Hecker, L
    Hlasta, DJ
    Hoekstra, WJ
    Poulter, B
    Andrade-Gordon, P
    de Garavilla, L
    Demarest, K
    Ericson, E
    Gunnet, J
    Hagman, W
    Look, R
    Moore, J
    Reynolds, CH
    Maryanoff, BE
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U913 - U914
  • [7] Discovery of potent nonpeptide vitronectin receptor (alpha(v)beta(3)) antagonists
    Keenan, RM
    Miller, WH
    Kwon, C
    Ali, FE
    Callahan, JF
    Calvo, RR
    Hwang, SM
    Kopple, KD
    Peishoff, CE
    Samanen, JM
    Wong, AS
    Yuan, CK
    Huffman, WF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (15) : 2289 - 2292
  • [8] Discovery and optimization of potent orally active small molecular thrombin receptor(PAR-1) antagonists.
    Kawahara, T
    Suzuki, S
    Matsuura, F
    Clark, RSJ
    Kogushi, M
    Kobayashi, H
    Hishinuma, L
    Sato, N
    Terauchi, T
    Kajiwara, A
    Matsuoka, T
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U21 - U21
  • [9] Discovery and optimization of potent orally active small molecular thrombin receptor PAR-1 antagonists.
    Kawahara, T
    Suzuki, S
    Kogushi, M
    Matsuoka, T
    Kobayashi, H
    Kajiwara, A
    Hishinuma, I
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U215 - U215
  • [10] Biphenyls as potent vitronectin receptor antagonists.: Part 3:: Squaric acid amides
    Urbahns, Klaus
    Haerter, Michael
    Albers, Markus
    Schmidt, Delf
    Stelte-Ludwig, Beatrix
    Brueggemeier, Ulf
    Vaupel, Andrea
    Keldenich, Joerg
    Lustig, Klemens
    Tsujishita, Hideki
    Gerdes, Christoph
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (22) : 6151 - 6154
12345