Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

被引：91
|
作者：
Lam, John S.
Seligson, David B.
Yu, Hong
Li, Ai
Eeva, Mervi
Pantuck, Allan J.
Zeng, Gang
Horvath, Steve
Belldegrun, Arie S.
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biostat, Los Angeles, CA USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA
来源：
BJU INTERNATIONAL | 2006年 / 98卷 / 02期
关键词：
flap endonuclease 1; Gleason grade; prostate cancer; tissue microarray; tumour markers; EUKARYOTIC DNA-REPLICATION; CELL NUCLEAR ANTIGEN; GENE FEN1; EXPRESSION; IDENTIFICATION; OPTIMIZATION; MITOXANTRONE; EXONUCLEASE; MICROARRAYS; PREDNISONE;
D O I：
10.1111/j.1464-410X.2006.06224.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
To investigate the expression and potential clinical usefulness of structure-specific flap endonuclease 1 (FEN-1) in human primary prostate cancer using tissue microarray technology, as FEN-1 was recently identified to be overexpressed in CL1.1, the most aggressive clone generated from the hormone-refractory prostate cancer cell line CL1.
引用
收藏
页码：445 / 451
页数：7
相关论文
共 50 条
  • [21] Molecular Characterization of Prostate Cancer with Associated Gleason Score Using Mass Spectrometry Imaging
    Randall, Elizabeth C.
    Zadra, Giorgia
    Chetta, Paolo
    Lopez, Begona G. C.
    Syamala, Sudeepa
    Basu, Sankha S.
    Agar, Jeffrey N.
    Loda, Massimo
    Tempany, Clare M.
    Fennessy, Fiona M.
    Agar, Nathalie Y. R.
    MOLECULAR CANCER RESEARCH, 2019, 17 (05) : 1155 - 1165
  • [22] BRE score in breast cancer, Gleason score in prostate cancer and tumor budding score in colorectal cancer?
    Karamitopoulou, E.
    Kondi-Pafiti, A.
    Koelzer, V.
    Karandrea, D.
    Gennatas, K.
    Patsouris, E.
    Zlobec, I.
    Lugli, A.
    VIRCHOWS ARCHIV, 2011, 459 : S155 - S155
  • [23] PROTEOMIC ANALYSIS OF URINARY EXTRACELLULAR VESICLES FROM HIGH GLEASON SCORE PROSTATE CANCER
    Fujita, Kazutoshi
    Kume, Hideaki
    Matsuzaki, Kyosuke
    Kawashima, Atsunari
    Ujike, Takeshi
    Nagahara, Akira
    Uemura, Motohide
    Miyagawa, Yasushi
    Tomonaga, Takeshi
    Nonomura, Norio
    JOURNAL OF UROLOGY, 2017, 197 (04): : E1320 - E1320
  • [24] Should we replace the Gleason score with the amount of high-grade prostate cancer?
    Vis, Andre N.
    Roemeling, Stijn
    Kranse, Ries
    Schroder, Fritz H.
    van der Kwast, Theo H.
    EUROPEAN UROLOGY, 2007, 51 (04) : 931 - 939
  • [25] Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer
    Kazutoshi Fujita
    Hideaki Kume
    Kyosuke Matsuzaki
    Atsunari Kawashima
    Takeshi Ujike
    Akira Nagahara
    Motohide Uemura
    Yasushi Miyagawa
    Takeshi Tomonaga
    Norio Nonomura
    Scientific Reports, 7
  • [26] Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer
    Fujita, Kazutoshi
    Kume, Hideaki
    Matsuzaki, Kyosuke
    Kawashima, Atsunari
    Ujike, Takeshi
    Nagahara, Akira
    Uemura, Motohide
    Miyagawa, Yasushi
    Tomonaga, Takeshi
    Nonomura, Norio
    SCIENTIFIC REPORTS, 2017, 7
  • [27] One core gleason score 6 prostate cancer: Clinically insignificant prostate cancer?
    Schafer, Georg
    Horninger, Wolfgang
    Pelzer, Alexandre E.
    Brunner, Andrea
    Mikuz, Gregor
    Bektic, Jasmin
    Bartsch, Georg
    JOURNAL OF UROLOGY, 2008, 179 (04): : 718 - 719
  • [28] The factors impacting on Gleason score upgrading in prostate cancer with initial low Gleason scores
    Huang, Tzu-Heng
    Li, Wei-Ming
    Ke, Hung-Lung
    Li, Ching-Chia
    Wu, Wen-Jeng
    Yeh, Hsin-Chih
    Wang, Yen-Chun
    Lee, Hsiang-Ying
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2025, 124 (02) : 145 - 150
  • [29] PSA Velocity Is Associated With Gleason Score in Radical Prostatectomy Specimen: Marker for Prostate Cancer Aggressiveness
    Loeb, Stacy
    Sutherland, Douglas E.
    D'Amico, Anthony V.
    Roehl, Kimberly A.
    Catalona, William J.
    UROLOGY, 2008, 72 (05) : 1116 - 1120
  • [30] Gleason score 5+3=8 prostate cancer: much more like Gleason score 9?
    Mahal, Brandon A.
    Muralidhar, Vinayak
    Chen, Yu-Wei
    Choueiri, Toni K.
    Hoffman, Karen E.
    Hu, Jim C.
    Sweeney, Christopher J.
    Yu, James B.
    Feng, Felix Y.
    Quoc-Dien Trinh
    Nguyen, Paul L.
    BJU INTERNATIONAL, 2016, 118 (01) : 95 - 101
12345